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Usage

Uses

Used in Pharmaceutical Industry:
2-[2-(4-Bromophenoxy)ethyl]-5-ethylpyridine is used as an impurity in Pioglitazone (P471000), a hypoglycemic drug with antidiabetic and antihyperglycemic actions. It plays a role in the development and formulation of this medication, which is utilized for managing blood sugar levels in patients with type 2 diabetes.
As an impurity, it is essential to monitor and control the levels of 2-[2-(4-Bromophenoxy)ethyl]-5-ethylpyridine in Pioglitazone to ensure the safety, efficacy, and quality of the final drug product. This may involve various analytical techniques and quality control measures to maintain the desired standards in the pharmaceutical industry.

Upstream product

• 85583-40-0 4-[2-(5-ethylpyridin-2-yl)ethoxy]aniline 
• 85583-54-6 4-[2-(5-ethyl-2-pyridyl)ethoxy]nitrobenzene 
• 350-46-9 4-Fluoronitrobenzene 
• 5223-06-3 5-ethyl-2-(2-hydroxyethyl)pyridine 

Downstream Products

• 105355-25-7 methyl 2-bromo-3-{4-[2-(5-ethyl-pyridin-2-yl)ethoxy]phenyl}propionate 

Relevant academic research and scientific papers

An improved process for pioglitazone and its pharmaceutically acceptable salt

An improved process for pioglitazone (1) is described. The process features high-yielding transformations employing inexpensive reagents and recoverable solvents.

Structural characterization of impurities in pioglitazone

In the pioglitazone bulk drug three prominent impurities I-III were detected up to concentrations of 0.1% (ranging from 0.05-0.1%) by reversed phase HPLC. These impurities were isolated from enriched mother liquor samples and characterized as 5-(4-hydroxybenzyl)-1,3-thiazolidine-2,4-dione (I) 5-(4-fluorobenzyl)-1,3-thiazolidine-2,4-dione (II), 2-[2-(4-bromophenoxy) ethyl-5-ethyl pyridine (III) based on their 1H, and 13C NMR, DEPT, Mass and IR spectral data. Structure elucidation and synthesis of these impurities is discussed.