85583-54-6

Basic information

• Product Name: 4-(2-(5-Ethyl-2-pyridyl)ethoxy)nitrobenzene
• Synonyms: 4-(2-(5-Ethyl-2-pyridyl)ethoxy)nitrobenzene;5-Ethyl-2-[2-(4-nitro-phenoxy)-ethyl]-pyridine
• CAS NO: 85583-54-6
• Molecular Formula: C₁₅H₁₆N₂O₃
• Molecular Weight: 272.3
• EINECS: 1312995-182-4
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 85583-54-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 57.0 to 61.0 °C
• Boiling Point: 449.348 °C at 760 mmHg
• Flash Point: 225.558 °C
• Appearance: /
• Density: 1.192 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-(2-(5-Ethyl-2-pyridyl)ethoxy)nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-(5-Ethyl-2-pyridyl)ethoxy)nitrobenzene(85583-54-6)
• EPA Substance Registry System: 4-(2-(5-Ethyl-2-pyridyl)ethoxy)nitrobenzene(85583-54-6)

Safety Data

• Hazardous Substances Data: 85583-54-6(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

Different sources of media describe the Uses of 85583-54-6 differently. You can refer to the following data:
1. Pioglitazone (P471000) impurity.
2. Pioglitazone

InChI:InChI=1/C15H16N2O3/c1-2-12-3-4-13(16-11-12)9-10-20-15-7-5-14(6-8-15)17(18)19/h3-8,11H,2,9-10H2,1H3

Upstream product

• 824-78-2 4-nitrophenol sodium salt 
• 144809-27-8 toluene-4-sulfonic acid 2-(5-ethylpyridin-2-yl)ethyl ester 
• 5223-06-3 5-ethyl-2-(2-hydroxyethyl)pyridine 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 85583-40-0 4-[2-(5-ethylpyridin-2-yl)ethoxy]aniline 
• 105355-27-9 Pioglitazone 
• 112529-15-4 5-{4-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl}-2,4-thiazolidinedione hydrochloride 
• 101931-09-3 methyl 3-{4-[2-acetoxy-2-(5-ethyl-2-pyridyl) ethoxy]phenyl}-2-bromopropionate 
• 145350-19-2 methyl 2-bromo-3-{4-[2-(5-ethyl-2-pyridyl)ethoxy]phenyl}propionate N-oxide 
• 101931-00-4 5-{4-[2-(5-ethyl-pyridin-2-yl)-2-hydroxyethoxy]benzyl}-2,4-thiazolidinedione 
• 105355-26-8 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2-imino-4-thiazolidinone 
• 105355-25-7 methyl 2-bromo-3-{4-[2-(5-ethyl-pyridin-2-yl)ethoxy]phenyl}propionate 
• 669716-58-9 2-[2-(4-bromophenoxy)ethyl]-5-ethyl-pyridine 

Relevant articles and documents

Method for preparing 4-[2-(5-ethyl-2-pyridyl)ethyoxyl]nitrobenzene

The invention relates to a method for preparing 4-[2-(5-ethyl-2-pyridyl)ethyoxyl]nitrobenzene. The method is characterized by comprising the following steps: dissolving 2-(5-ethyl-2-pyridyl)ethyl alcohol in halohydrocarbon, adding inorganic alkali and a p

An improved process for pioglitazone and its pharmaceutically acceptable salt

An improved process for pioglitazone (1) is described. The process features high-yielding transformations employing inexpensive reagents and recoverable solvents.

PROCESS FOR THE PREPARATION OF 5-[[4-[2-(5-ETHYL-2-PYRIDINYL)ETHOXY]PHENYL] METHYL]-2,4-THIAZOLIDINEDIONE

A process for the preparation of 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione (formula 1) comprising a. reacting diazonium salt of 4-[2-(5-Ethyl-2-pyridyl) ethoxy] amino- benzene, compound of formula 2, with acrylamide, aqueous HX (wherein X is Br or Cl), under meerwein arylation conditions to yield compound of formula 3; b. condensing compound of formula 3 with thiourea to obtain compound of formula 4; and c. converting compound of formula 4 to compound of formula 1.