66982-50-1Relevant articles and documents
Thiete Dioxides as Templates Towards Twisted Scaffolds and Macrocyclic Structures
Baumann, Andreas N.,Didier, Dorian,Mayer, Peter,Reiners, Felix,Siegle, Alexander F.,Trapp, Oliver
, p. 6029 - 6035 (2020/05/16)
Thiete dioxide units have been employed as a template for further functionalization through C?H activation strategies. Using simple thiete dioxide building blocks, a new library of axially chiral molecules has been synthesized that owe their stability to electrostatic interactions in the solid state. Similar starting materials were further engaged in the formation of cyclic trimeric structures, opening the pathway to unprecedented macrocyclic ring systems.
Chemodivergent and Stereoselective Access to Fused Isoxazoline Azetidines and Thietanes through [3 + 2]-Cycloadditions
Baumann, Andreas N.,Reiners, Felix,Juli, Thomas,Didier, Dorian
, p. 6736 - 6740 (2018/11/02)
By combining efficient methodologies for the preparation of substituted azetines and thietes with a highly regio- and diastereoselective [3 + 2]-cycloaddition, a straightforward pathway for the synthesis of fused isoxazoline azetidines and thietanes has been designed. With minimal steps and starting from commercial sources, a new library of elaborated architectures was synthesized opening up a new class of molecules with large potential in pharmacology. Finally, a retro [2 + 2]-cycloaddition leading to substituted isoxazoles is described.
