25903-17-7

Basic information

• Product Name: 3-Phenyl-2H-thiete 1,1-dioxide
• Synonyms: 3-Phenyl-2H-thiete 1,1-dioxide
• CAS NO: 25903-17-7
• Molecular Formula: C₉H₈O₂S
• Molecular Weight: 180.22362
• Mol File: 25903-17-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 393°Cat760mmHg
• Flash Point: 258.3°C
• Appearance: /
• Density: 1.354g/cm³
• Vapor Pressure: 4.99E-06mmHg at 25°C
• Refractive Index: 1.626
• CAS DataBase Reference: 3-Phenyl-2H-thiete 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenyl-2H-thiete 1,1-dioxide(25903-17-7)
• EPA Substance Registry System: 3-Phenyl-2H-thiete 1,1-dioxide(25903-17-7)

Safety Data

• Hazardous Substances Data: 25903-17-7(Hazardous Substances Data)

Usage

General Description

3-Phenyl-2H-thiete 1,1-dioxide, also known as phenylthioacetaldehyde S-oxide, is a chemical compound with the molecular formula C8H8O2S. It is a sulfur-containing heterocyclic compound with a cyclic ether and a thioether functionality. 3-Phenyl-2H-thiete 1,1-dioxide is commonly used in organic synthesis and pharmaceutical research as a building block for making various functionalized molecules. It is also known for its potential biological activities and has been studied for its antimicrobial and antifungal properties. Additionally, 3-Phenyl-2H-thiete 1,1-dioxide has shown promise in medicinal chemistry, particularly in the development of new drugs for the treatment of various diseases.

InChI:InChI=1/C9H8O2S/c10-12(11)6-9(7-12)8-4-2-1-3-5-8/h1-6H,7H2

Upstream product

• 100-59-4 phenylmagnesium chloride 
• 66982-50-1 3-phenyl-3-hydroxythietane 1,1-dioxide 
• 66982-46-5 3-phenyl-3-hydroxythietane 
• 77543-73-8 3-phenylthiete 1,1-dioxidebis(triphenylphosphine)platinum⁽⁰⁾ 
• 670-54-2 ethenetetracarbonitrile 

Relevant articles and documents

Parallel Approaches for the Functionalization of Thietes: α-Metalation versus C-H Activation

For the first time, an approach to 3,4-disubstituted thietes was developed through two complementary paths. While the first one relies on α-metalation, the second is based on direct C-H functionalization. A new library of sophisticated sulfur-containing four-membered rings is described, paving the way to new bioactive analogues and small heterocycle incorporation.

Chemodivergent and Stereoselective Access to Fused Isoxazoline Azetidines and Thietanes through [3 + 2]-Cycloadditions

By combining efficient methodologies for the preparation of substituted azetines and thietes with a highly regio- and diastereoselective [3 + 2]-cycloaddition, a straightforward pathway for the synthesis of fused isoxazoline azetidines and thietanes has been designed. With minimal steps and starting from commercial sources, a new library of elaborated architectures was synthesized opening up a new class of molecules with large potential in pharmacology. Finally, a retro [2 + 2]-cycloaddition leading to substituted isoxazoles is described.