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Usage

Uses

Used in Organic Synthesis:
3-Phenyl-2H-thiete 1,1-dioxide is used as a key building block in organic synthesis for the creation of a variety of functionalized molecules. Its unique structure allows for the development of complex organic compounds that can be utilized in various chemical and pharmaceutical applications.
Used in Pharmaceutical Research:
In pharmaceutical research, 3-Phenyl-2H-thiete 1,1-dioxide is employed as a precursor for the synthesis of new drugs. Its potential biological activities, including antimicrobial and antifungal properties, make it a valuable compound in the discovery and development of novel therapeutic agents.
Used in Medicinal Chemistry:
3-Phenyl-2H-thiete 1,1-dioxide is used in medicinal chemistry for the development of new drugs to treat various diseases. Its unique sulfur-containing heterocyclic structure provides a foundation for designing molecules with specific therapeutic properties, contributing to advancements in the treatment of different medical conditions.
Used in Antimicrobial Applications:
3-Phenyl-2H-thiete 1,1-dioxide is used as an antimicrobial agent due to its potential biological activities. It can be utilized in the development of new antimicrobial drugs to combat resistant bacterial strains and contribute to the treatment of various infections.
Used in Antifungal Applications:
Similarly, 3-Phenyl-2H-thiete 1,1-dioxide is used as an antifungal agent, leveraging its biological properties to develop new antifungal drugs. This can aid in the treatment of fungal infections and the management of conditions caused by fungal pathogens.

InChI:InChI=1/C9H8O2S/c10-12(11)6-9(7-12)8-4-2-1-3-5-8/h1-6H,7H2

Upstream product

• 77543-73-8 3-phenylthiete 1,1-dioxidebis(triphenylphosphine)platinum⁽⁰⁾ 
• 670-54-2 ethenetetracarbonitrile 
• 100-59-4 phenylmagnesium chloride 
• 66982-50-1 3-phenyl-3-hydroxythietane 1,1-dioxide 
• 66982-46-5 3-phenyl-3-hydroxythietane 

Relevant academic research and scientific papers

Parallel Approaches for the Functionalization of Thietes: α-Metalation versus C-H Activation

For the first time, an approach to 3,4-disubstituted thietes was developed through two complementary paths. While the first one relies on α-metalation, the second is based on direct C-H functionalization. A new library of sophisticated sulfur-containing four-membered rings is described, paving the way to new bioactive analogues and small heterocycle incorporation.

Thiete Dioxides as Templates Towards Twisted Scaffolds and Macrocyclic Structures

Thiete dioxide units have been employed as a template for further functionalization through C?H activation strategies. Using simple thiete dioxide building blocks, a new library of axially chiral molecules has been synthesized that owe their stability to electrostatic interactions in the solid state. Similar starting materials were further engaged in the formation of cyclic trimeric structures, opening the pathway to unprecedented macrocyclic ring systems.

Chemodivergent and Stereoselective Access to Fused Isoxazoline Azetidines and Thietanes through [3 + 2]-Cycloadditions

By combining efficient methodologies for the preparation of substituted azetines and thietes with a highly regio- and diastereoselective [3 + 2]-cycloaddition, a straightforward pathway for the synthesis of fused isoxazoline azetidines and thietanes has been designed. With minimal steps and starting from commercial sources, a new library of elaborated architectures was synthesized opening up a new class of molecules with large potential in pharmacology. Finally, a retro [2 + 2]-cycloaddition leading to substituted isoxazoles is described.

PLATINUM(0) COMPLEXES OF 3-ARYLTHIETE 1,1-DIOXIDES

3-Phenyl- and 3-p-bromophenyl-thiete 1,1-dioxides react with and to give the complexes (R=Ph, p-BrC6H4; M=P, As).