67007-00-5

Upstream product

• 75-05-8 acetonitrile 
• 371-40-4 4-fluoroaniline 
• 352-34-1 4-fluoro-1-iodobenzene 
• 124-42-5 acetamidine hydrochloride 

Downstream Products

• 1002107-34-7 1-(4-fluorophenyl)-2-methyl-1H-imidazole-5-carbaldehyde 
• 26296-74-2 (2-methyl-5-fluoro-1H-indol-3-yl)(phenyl)methanone 
• 1139921-56-4 6-fluoro-2-benzylquinoline 
• 87356-53-4 3-(4-Fluoro-phenyl)-2-methyl-3H-pyrimidin-4-one 
• 87356-69-2 3-(4-fluorophenyl)-2-methyl-6-phenylpyrimidin-4(3H)-one 

Relevant academic research and scientific papers

Practical Synthesis of Benzimidazo[1,2- A[quinolines via Rh(III)-Catalyzed C-H Activation Cascade Reaction from Imidamides and Anthranils

We report a novel and practical one-pot Rh(III)-catalyzed strategy to construct benzimidazo[1,2-a]quinolines from readily available imidamides and anthranils. The cascade reaction proceeds via a C-H amination-cyclization-cyclization process in ionic liquid without any additives and possesses simple operation, moderate-to-high yield, and broad substrate scope features, which will provide the reference for the construction of biologically active fused benzimidazoles.

Synthesis of indoles and quinazolines via additive-controlled selective C-H activation/annulation of N -arylamidines and sulfoxonium ylides

Selective synthesis of indole and quinazoline products was achieved through a precise control of the C-H activation/annulation by changing the additives from NaOAc to CuF2/CsOAc. This strategy constructs indole and quinazoline scaffolds efficie

Synthesis of 2-Substituted Quinolines via Rhodium(III)-Catalyzed C–H Activation of Imidamides and Coupling with Cyclopropanols

An efficient synthesis of 2-substituted quinolines from readily available cyclopropanols and imidamides has been developed, where the cyclopropanol acts as a C3 synthon. With the assistance of a bifunctional imidamide directing group, the reaction occurred via sequential C–H/C–C cleavage and C–C/C–N bond formation. (Figure presented.).

Synthesis, characterization of bridged bis(amidinate) lanthanide amides and their application as catalysts for addition of amines to nitriles for monosubstituted N-arylamidines

A series of lanthanide amide complexes supported by bridged bis(amidinate) ligand L, LLnNHAr1(DME) (L = [Me3SiNC(Ph)N(CH 2)3NC(Ph)NSiMe3], Ar1 = 2,6- iPr2C6

Ligand-free copper-catalyzed arylation of amidines

Copper-catalyzed cross-coupling reactions of amidine salts were utilized to synthesize monoarylated amidines in moderate to high yields with ligand-free conditions. DMF was the superior solvent for the N-arylation of benzamidines, while MeCN was used in the formation of N-aryl amidines in moderate to high yield.(Figure Presented)

Synthesis and molecular structures of lanthanocene amide complexes and their catalytic activity for addition of amines to nitriles

Reaction of (CH3C5H4)2LnCl(THF) with NaNHAr in a 1:1 molar ratio in THF afforded the amide complexes (CH3C5H4)2LnNHAr(THF) [(Ar = 2,6-Me2C6H

Addition of amines to nitriles catalyzed by ytterbium amides: An efficient one-step synthesis of monosubstituted N-arylamidines

A one-step synthesis of monosubstituted N-arylamidinates via addition of amines to nitriles catalyzed by ytterbium amides is reported. The reactions with various substrates give the products in good to excellent yields with 5 mol % ytterbium at 100 °C under solvent-free conditions.

Synthesis and evaluation of new difluoromethyl azoles as antileishmanial agents

Several compounds of great pharmacological interest contain the triazole and imidazole rings. In order to find new drugs with antileishmanial activity we have synthesized and evaluated new imidazole and triazole compounds carrying either the carbaldehyde or the difluoromethylene functionalities against promastigote forms of Leishmania amazonensis. Among the compounds tested difluoromethylene azoles 4b and 8f have inhibited the parasite growth significantly. Our results show that the introduction of the difluoromethylene moieties has turned the inactive carbaldehydes into active antileishmanial compounds.

Synthesis and Biological Evaluation of 6-Substituted 3-Aryl-2-methyl-4(3H)-pyrimidones

6-Substituted 3-aryl-2-methyl-4(3H)-pyrimidones (III) have been prepared by the reaction of N-arylacetamidines (II) with various diplorophiles like ethyl propiolate, ethyl tetrolate and ethyl phenylpropiolate.The structure of the products has been confirm