6708-06-1

Usage

Uses

Used in Pharmaceutical Industry:
(5aS)-2,3,5aβ,6,7,8-Hexahydro-1H,5H-dipyrrolo[1,2-a:1',2'-d]pyrazine-5,10(10aβH)-dione is used as an intermediate compound for the synthesis of various pharmaceutical agents. Its unique structure may contribute to the development of new drugs with specific therapeutic properties.
Used in Chemical Research:
In the field of chemical research, (5aS)-2,3,5aβ,6,7,8-Hexahydro-1H,5H-dipyrrolo[1,2-a:1',2'-d]pyrazine-5,10(10aβH)-dione can be utilized as a starting material or a building block for the creation of more complex molecules with potential applications in various industries.
Used in Material Science:
(5aS)-2,3,5aβ,6,7,8-Hexahydro-1H,5H-dipyrrolo[1,2-a:1',2'-d]pyrazine-5,10(10aβH)-dione may also find use in material science, where its unique properties could be exploited to develop new materials with specific characteristics, such as improved stability or reactivity.

Upstream product

• 147-85-3 L-proline 

Downstream Products

• 454693-98-2 5a-benzyl-octahydro-dipyrrolo[1,2-a;1',2'-d]pyrazine-5,10-dione 
• 114026-76-5 (-)-(2R,3R)-trans-2,3-bis(hydroxydiphenylmethyl)-1,4-dioxaspiro[4.5]decane 
• 1231934-91-0 C₁₀H₁₄N₂O₂*C₃₄H₃₄O₄ 
• 18531-94-7 (R)-1,1'-Bi-2-naphthol 
• 18531-99-2 (S)-[1,1']-binaphthalenyl-2,2'-diol 
• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 20488-28-2 L-prolyl-L-proline 
• 128425-02-5 L-FDAA-L-Pro 
• 454693-93-7 5,10-dioxo-hexahydro-dipyrrolo[1,2-a;1',2'-d]pyrazine-5a-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

PdPb-Catalyzed decarboxylation of proline to pyrrolidine: Highly selective formation of a biobased amine in water

Amino acids have huge potential as platform chemicals in the biobased industry. Pd-catalyzed decarboxylation is a very promising route for the valorization of these natural compounds derived from protein waste or fermentation. We report that the highly abundant and nonessential amino acid L-proline is very reactive in the Pd-catalyzed decarboxylation. Full conversions are obtained with Pd/C and different Pd/MeOx catalysts; this allowed the identification of the different side reactions and the mapping of the reaction network. Due to the high reactivity of pyrrolidine, the selectivity for pyrrolidine was initially low. By carefully modifying Pd/ZrO2 with Pb in a controlled mannervia two incipient wetness impregnation stepsthe selectivity increased remarkably. Finally, a thorough investigation of the reaction parameters resulted in an increased activity of this modified catalyst and an even further enhanced selectivity under a low H2 pressure of 4 bar at 235 °C in water. This results in a very selective and sustainable production route for the highly interesting pyrrolidine.

Heterocomplexation of a chiral dipeptide and quantitative enantiomeric enrichment of nonracemic 1,1′-Bi-2-naphthol

(Chemical Equation Presented) Heterocomplexation of a chiral host to a racemic guest has been discovered. A cyclic dipeptide generated from (S)-proline alkyl ester undergoes an achiroselective complexation to both the enantiomers of racemic BINOL in benzene to yield a crystalline heterocomplex bearing the solvent molecules. However, complexation crystallization does not occur between the diptide and either enantiomer of BINOL under similar conditions. The difference in complexation behavior has been successfully applied in the enantiomeric enrichment of nonracemic BINOLs, and almost quantitative separation of the excess enantiomer from racemic BINOL was achieved.