671240-58-7Relevant articles and documents
Novel synthetic route of aryl-aminopyrazine
Kuse, Masaki,Kondo, Nobuhiro,Ohyabu, Yuki,Isobe, Minoru
, p. 835 - 840 (2007/10/03)
We report a novel synthetic route of aryl-aminopyrazine through a new cyclization reaction by using a hydroxylamine. Starting from Boc-glycine and aminonitrile, the aminopyrazine ring was prepared in several steps. After trifluoromethane sulfonylation of the aminopyrazinone, the resultant triflate was subjected to Suzuki-Miyaura coupling reaction with aryl boronic acid to afford coelenteramine.