40040-81-1

Basic information

• Product Name: 2-AMINO-3-BENZYL-5-(4-METHOXYPHENYL)PYRAZINE
• Synonyms: 2-AMINO-3-BENZYL-5-(4-METHOXYPHENYL)PYRAZINE;5-(4-METHOXYPHENYL)-3-(PHENYLMETHYL)-PYRAZINAMINE;2-AMINO-3-BENZYL-5-(4-METHOXYPHENYL)PYRAZINE 98%;3-benzyl-5-(4-methoxyphenyl)pyrazin-2-amine
• CAS NO: 40040-81-1
• Molecular Formula: C₁₈H₁₇N₃O
• Molecular Weight: 291.35
• Mol File: 40040-81-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 461.4°C at 760 mmHg
• Flash Point: 232.8°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 1.08E-08mmHg at 25°C
• Refractive Index: 1.624
• PKA: 3.27±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-3-BENZYL-5-(4-METHOXYPHENYL)PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3-BENZYL-5-(4-METHOXYPHENYL)PYRAZINE(40040-81-1)
• EPA Substance Registry System: 2-AMINO-3-BENZYL-5-(4-METHOXYPHENYL)PYRAZINE(40040-81-1)

Safety Data

• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 40040-81-1(Hazardous Substances Data)

Usage

General Description

2-AMINO-3-BENZYL-5-(4-METHOXYPHENYL)PYRAZINE is a chemical compound with the molecular formula C19H17N3O. It is a complex organic compound with a pyrazine core and substituents including an amino group, a benzyl group, and a methoxyphenyl group. 2-AMINO-3-BENZYL-5-(4-METHOXYPHENYL)PYRAZINE has potential applications in the pharmaceutical and chemical industries, particularly in the development of new drugs and materials. Its precise properties and potential uses would depend on further research and testing.

InChI:InChI=1/C18H17N3O/c1-22-15-9-7-14(8-10-15)17-12-20-18(19)16(21-17)11-13-5-3-2-4-6-13/h2-10,12H,11H2,1H3,(H2,19,20)

Upstream product

• 1823-76-3 p-methoxy-isonitrosoacetophenone 
• 55379-75-4 2-amino-3-phenylpropanenitrile 
• 5720-07-0 4-methoxyphenylboronic acid 
• 174680-55-8 2-amino-5-bromo-3-phenylmethylpyrazine 
• 123437-73-0 3-benzyl-5-(4-methoxy-phenyl)-1-oxy-pyrazin-2-ylamine 
• 100-39-0 benzyl bromide 
• 108-88-3 toluene 
• 151427-04-2 2-(p-methoxyphenyl)ethan-1,2-dion-1-oxime sodium salt 
• 185148-51-0 3-benzyl-2-pyrazinamine 
• 671240-61-2 5-N-(p-toluenesulfonyl)amide-6-benzyl-2-O-trifluoromethanesulfonyloxy-pyrazine 
• 671240-60-1 N-(3-benzyl-5-hydroxy-pyrazin-2-yl)-4-methyl-benzenesulfonamide 
• 671240-54-3 [(1-cyano-2-phenyl-ethylcarbamoyl)-methyl]-carbamic acid tert-butyl ester 
• 671240-57-6 3-benzyl-piperazine-2,5-dione 2-oxime 
• 671240-58-7 5-amino-6-benzyl-3,6-dihydro-1H-pyrazin-2-one 

Downstream Products

• 156686-47-4 2-tert-butyl-6-(p-methoxyphenyl)-8-benzyl-3,7-dihydroimidazo<1,2-a>pyrazin-3-one 
• 37156-84-6 4-(5-amino-6-benzyl-pyrazin-2-yl)-phenol 
• 49842-01-5 N-[3-benzyl-5-(4-methoxy-phenyl)-pyrazin-2-yl]-acetamide 
• 50909-86-9 2,8-dibenzyl-6-(4-hydroxyphenyl)imidazo[1,20-a]pyrazin-3(7H)one 
• 50909-83-6 2-(phenylmethyl)-6-(4-methoxyphenyl)-8-benzylimidazo[1,2-a]pyrazin-3(7H)-one 
• 1338220-64-6 1-[3-benzyl-5-(4-hydroxyphenyl)pyrazin-2-yl]-3-(4-hydroxyphenyl)urea 
• 1238832-12-6 5-(4-acetoxyphenyl)-3-benzyl-2-(phenylthioacetylamino)pyrazine 
• 1238832-11-5 5-(4-acetoxyphenyl)-3-benzyl-2-(phenylacetylamino)pyrazine 
• 1238831-99-6 3-benzyl-5-(4-methoxyphenyl)-2-(phenylthioacetylamino)pyrazine 
• 50909-85-8 3-benzyl-5-(p-hydroxyphenyl)-2-(phenylacetamido)pyrazine 
• 1238832-33-1 3-benzyl-2-(4-hydroxybenzyl)sulfonylamino-5-(4-hydroxyphenyl)pyrazine 
• 1238832-32-0 5-(4-acetoxyphenyl)-3-benzyl-2-[(4-hydroxybenzyl)sulfonylamino]pyrazine 
• 1238832-31-9 5-(4-acetoxyphenyl)-3-benzyl-2-bis(4-iodobenzylsulfonyl)aminopyrazine 
• 1238832-22-8 3-Benzyl-5-(4-hydroxyphenyl)-2-[(4-nitrophenyl)sulfonylamino]pyrazine 

Relevant articles and documents

ATP-INDEPENDENT BIOLUMINESCENT REPORTER VARIANTS TO IMPROVE IN VIVO IMAGING

Provided herein are chemically modified luciferase substrates for spectrally shifted emission and enhanced water solubility. Provided herein are engineered luciferases. Moreover, provided herein are new ATP-independent bioluminescent reporters which have improved biochemical and photophysical properties and are expected to have broad applications. Finally, provided herein are spectral-resolved triple-color bioluminescent systems, suitable for flexible and convenient approaches to monitor multiple biological events in either qualitative or quantitative manners.

Coelenterazine analog and preparing method and application thereof

The invention discloses a coelenterazine analog and a preparing method and application thereof. The coelenterazine analog has the general structure formula (I) shown in the description, wherein R1, R2 and R3 in the formula are different substituents. According to application of the compound as a bioluminescence substrate, the existence and quantity (including the enzyme level, the cell level and the animal level) of coelenterazine luciferase can be detected with bioluminescence, and the in vitro, cell and in vivo distribution imaging of luciferase can be detected; the compound can serve as a report signal to detect the pharmacologic action and the toxic effect of medicine on the enzyme level, the cell level and the animal level under the existence of luciferase.

Novel synthetic route of aryl-aminopyrazine

We report a novel synthetic route of aryl-aminopyrazine through a new cyclization reaction by using a hydroxylamine. Starting from Boc-glycine and aminonitrile, the aminopyrazine ring was prepared in several steps. After trifluoromethane sulfonylation of the aminopyrazinone, the resultant triflate was subjected to Suzuki-Miyaura coupling reaction with aryl boronic acid to afford coelenteramine.