67139-38-2Relevant articles and documents
Aurones and Analogues: Promising Heterocyclic Scaffolds for Development of Antioxidant and Antimicrobial Agents
Irshad,Ali,Iram,Ahamad,Saleem,Saadia,Batool,Kanwal,Tabassum
, p. 1519 - 1527 (2019/08/21)
Synthesis of some new multi-functional analogues of 2′-hydroxy chalcone containing isoxazole and pyrazole functions were synthesized, and their pharmacological activity was tested. Chalcone derivatives were synthesized by the reaction of 2′-hydroxy acetophenone with various substituted benzaldehydes in a basic medium. Aurones were isolated upon treatment with mercuric acetate. Synthesized chalcones and aurones were converted into the corresponding isoxazole and pyrazole derivatives upon their reaction with hydroxylamine hydrochloride or hydrazine hydrate, respectively. Structures of the compounds were confirmed by spectroscopic methods. All synthesized compounds were tested for antioxidant and antibacterial potential. Some of those demonstrated excellent antioxidant activity, and one product was identified as a promising antimicrobial candidate.
β-cyclodextrin (β-CD) as a supramolecular catalyst for the synthesis of isoxazoles and thiopyrimidines and their antimicrobial screening
Chate, Asha V.,Gill, Charansingh H.
, p. 93 - 102 (2017/03/30)
Background: Isoxazole and pyrimidines are interesting heterocyclic molecules, which are present as structural motif in numerous natural products synthetic drugs. Isoxazole and thiopyrimidines exhibit antidiabetic, cytotoxic tuberculostatic, and anticonvul
