67176-26-5Relevant academic research and scientific papers
Lewis Acid-Mediated Cyanation of Phenols Using N-Cyano-N-phenyl-p-toluenesulfonamide
Zhang, Wu,Li, Tao,Wang, Qingli,Zhao, Wanxiang
supporting information, p. 4914 - 4918 (2019/11/03)
Lewis acid-mediated cyanation of phenol derivatives with N-cyano-N-phenyl-p-toluenesulfonamide (NCTS) has been developed. The reaction proceeded efficiently with high regioselectivity to produce aromatic nitriles in moderate to excellent yields, which provides a direct and practical access to valuable products. (Figure presented.).
NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE
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Page/Page column 22, (2008/06/13)
[From equivalent EP1710233A1] The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; R2 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, aryl, aralkyl, arylalkenyl, aryloxy-lower alkyl, heteroaryl, heteroaryl-lower alkyl, etc; R3, R4, R5 and R6 are each hydrogen, halogen, cyano, lower alkyl, halo-lower alkyl, lower alkoxy, hydroxy, aryl, etc; provided that at least one of R3, R4, R5 and R6 is other than hydrogen. Compound (I) of the present invention shows a potent adenosine A2A receptor antagonistic activity, and are useful for treating or preventing a disease mediated by adenosine A2A receptors such as motor function disorders, depression, anxiety disorders, cognitive function disorders, cerebral ischemia disorders, restless legs syndrome and the like.
Naphthopyrans annelated in C5-C6, their preparation and compositions and (CO)polymer matrices containing them
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, (2008/06/13)
The present invention relates to novel compounds of the naphthopyran type which have an annelated carbocycle in position 5,6. These compounds are of formula (I) given below: in which A is an alicyclic ring which is optionally annelated with an aromatic ring and in which two adjacent R3 can together form at least one ring, for example a benzo group. These compounds (I) possess interesting photochromic properties. The invention also relates to the method of preparing these compounds (I), as well as their applications as photochromes and compositions and (co)polymer matrices comprising them.
A Novel Route to Isoannulated Heteroaromatic Compounds, 1. - Synthesis and Reactions of Furofurans, Thienofurans, Furobenzofurans, and Benzothienofurans
Eberbach, Wolfgang,Laber, Norbert,Bussenius, Joerg,Fritz, Hans,Rihs, Grety
, p. 975 - 996 (2007/10/02)
A general method for the synthesis of furo- and thienofurans 4 - 7 has been developed.The reaction principle is based on the thermal transformation of suitably structured epoxyhexenynes (15 -19) following the general reaction sequence 1 -> 2 -> 3 (annulation type A).Derivatives of the so far unknown diheteropentalenes furofuran (4b, c, d, g, h), furobenzofuran (6b, d, e, 45) as well as benzothienofuran (7b, d) are obtained by short-time thermolysis.Likewise two representatives of the previously reported thienofuran system are prepared (5b, c).By flash vacuum thermolysis the benzo-annulated epoxyhexenyne 19b rearranges in poor yield to the isobenzofuran 52 (identified as dimethyl acetylenedicarboxylate adduct 47) and 2-cyano-α-naphthol (46).The structure of the furofuran 4b has been established by X-ray structural analysis.A mechanistic explanation of the transformation of the epoxyhexenynes to diheteropentalenes is proposed.Indications for the occurrence of carbenes as product-determining species are obtained with the phenylcyano-substituted oxiranes 15c, h and 17e which - in addition to the furofurans 4c, h and 6e - lead to the furylindenes 31c, h/32c, h and 41, resp..The Diels-Alder reactivity of the furo- and thienofurans 4g, 5b, c, and 6b has been examined.Key Words: Pentalenes, dihetero- / Cyclizations, 1,7-dipolar / Carbonyl ylides / Cycloallenes / Diels-Alder reactions / o-Quinodimethanes, hetero analogues
Process for ortho-cyanation of phenols or phenylamines
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, (2008/06/13)
A process for ortho-cyanation of phenols or phenylamines which comprises reacting a phenyl compound having hydroxy or optionally substituted amino or cyclic amino, of which ortho position is vacant, with trichloroacetonitrile, C1 -C5 alkyl thiocyanate or C6 -C12 aryl thiocyanate in the presence of a boron trihalide and treating the resultant product with an alkali is provided, and said process is useful in the synthesis of intermediates for medicinals or pesticides.
A New Route to 4-Hydroxytetralones and 1-Naphthols
Broom, Nigel J. P.,Sammes, Peter G.
, p. 465 - 470 (2007/10/02)
The lithium salts, derived from position 3 of phthalides by treatment with hindered bases, participate in Michael addition reactions with a variety of conjugated olefins.For singly activated olefins the conjugate anion reacts intramolecularly with the lactone group to produce 4-hydroxytetralones in moderate to good yield.Dehydration of these hydroxytetralones, by brief treatment with acid, produces the corresponding α-naphthol.Substituted phthalides react similarly making the method a general one for the production of substituted α-naphthols.
