67180-08-9

Basic information

• Product Name: (2S,3S)-threo-3-Methyl-4-phenyl-2-butanol
• Synonyms: (2S,3S)-threo-3-Methyl-4-phenyl-2-butanol
• CAS NO: 67180-08-9
• Molecular Weight: 164.247
• Mol File: 67180-08-9.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: (2S,3S)-threo-3-Methyl-4-phenyl-2-butanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-threo-3-Methyl-4-phenyl-2-butanol(67180-08-9)
• EPA Substance Registry System: (2S,3S)-threo-3-Methyl-4-phenyl-2-butanol(67180-08-9)

Safety Data

• Hazardous Substances Data: 67180-08-9(Hazardous Substances Data)

Upstream product

• 196106-01-1 (R)-3-methyl-2-phenylbutan-1-amine 
• 7384-80-7 (S)-2-methyl-3-phenylpropan-1-ol 
• 7653-95-4 1,2-cis,trans-Dimetrhyl-3-phenylcyclopropan 
• 90106-96-0 Bromomethyl-dimethyl-((E)-1-methyl-3-phenyl-allyloxy)-silane 
• 925669-95-0 2,3-cis-epoxybutane 
• 6921-34-2 benzylmagnesium chloride 
• 108-88-3 toluene 
• 104174-46-1 C₁₁H₁₄O 
• 100-39-0 benzyl bromide 
• 7653-96-5 r-1-phenyl-cis-2,cis-3-dimethylcyclopropane 
• 25181-26-4 (1α,2β,3β)-1,2-dimethyl-3-phenylcyclopropane 
• 917-64-6 methyl magnesium iodide 
• 5445-77-2 2-benzylpropionaldehyde 
• 21490-63-1 2,3-trans-epoxybutane 

Downstream Products

• 3968-91-0 (Z)-1-phenyl-2-methyl-2-butene 
• 125830-10-6 (2R*,3R*)-2,3-dimethyl-4-phenylbutanecarbonitrile 
• 125830-08-2 (2S*,3R*)-2-methoxy-3-methyl-4-phenylbutane 
• 125830-10-6 (2S*,3R*)-2,3-dimethyl-4-phenylbutanecarbonitrile 

Relevant articles and documents

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A copper(I)-mediated cross-coupling of stereodefined secondary alkyllithiums with bromoalkynes provided stereodefined alkynes with high diastereoselectivity (dr up to 98:2). This cross-coupling was extended to various secondary alkyllithiums bearing a remote oxygen functionality, and the alkyne synthesis was also performed with optically enriched alkyl iodides (up to 99% ee) providing, after cross-coupling, alkynes bearing two stereocenters (dr = 93:7; up to 99% ee).

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