672-25-3

Usage

Uses

Used in Pharmaceutical Industry:
(Aminomethylene)malononitrile is used as a key intermediate for the synthesis of various pharmaceuticals. Its ability to undergo multiple chemical transformations allows for the creation of diverse drug molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (aminomethylene)malononitrile is employed as a precursor for the development of new agrochemicals. Its reactivity enables the synthesis of a wide range of compounds with potential applications in crop protection and pest control.
Used in Fine Chemicals Industry:
(Aminomethylene)malononitrile is utilized as a versatile building block in the synthesis of various fine chemicals. Its unique properties and reactivity contribute to the development of specialty chemicals for a range of applications, including fragrances, dyes, and other high-value products.
Used in Organic Chemistry Research:
As a highly reactive intermediate, (aminomethylene)malononitrile is extensively used in organic chemistry research for exploring new synthetic pathways and developing innovative chemical transformations. Its potential for various reactions makes it an essential component in the advancement of organic chemistry and the discovery of new compounds with unique properties and applications.

InChI:InChI=1/C4H3N3/c5-1-4(2-6)3-7/h1H,5H2

Upstream product

• 672-81-1 2-(methoxymethylene)malononitrile 
• 290-87-9 1,3,5-Triazine 
• 109-77-3 malononitrile 
• 454-50-2 tricyanomethane 
• 38109-69-2 N,O-bis(trimethylsilane)acetamide 
• 123-06-8 Ethoxymethylenemalononitrile 
• 21689-52-1 aminomethylene cyanacetamide 

Downstream Products

• 76574-45-3 4-amino-2-ethylpyrimidine-5-carbonitrile 
• 698-29-3 2-methyl-4-amino-5-cyanopyrimidine 
• 16357-69-0 4-amino-5-cyanopyrimidine 
• 872826-79-4 4-amino-2-benzyl-pyrimidine-5-carbonitrile 
• 1867-38-5 4-chlorobenzylidenemalonodinitrile 
• 16849-88-0 1-(dimethylamine)-2,2-dicyanoethylene 
• 53630-83-4 3-tert.-Butylamino-2-cyan-acrylnitril 
• 2826-28-0 p-(N-dimethylamino benzylidene) malononitrile 
• 106509-98-2 (+/-)-2-[4-(5-chloro-3-fluoropyridin-2-yloxy)-phenoxy]-propionic acid-(2,2-dicyanovinyl)amide 
• 67247-92-1 2,4-dichloro-2-phenyl-2λ⁵-[1,3,2]diazaphosphinine-5-carbonitrile 

Relevant academic research and scientific papers

Oxidative peptide bond formation of glycine-amino acid using 2-(aminomethyl)malononitrile as a glycine unit

Amide linkage of glycine-amino acid was synthesized by coupling of substituted 2-(aminomethyl)malononitrile as a C-terminal glycine unit and N-terminal amine using CsOAc and O2in an aqueous solution. This is a coupling reagent-free and catalyst-free peptide synthesisviaoxidative amide bond formation. Various tripeptides and tetrapeptides were synthesized efficiently and the sulfide moiety is inert even under an oxygen atmosphere.

PROCESS FOR THE PREPARATION OF PYRIMIDINE DERIVATIVES

A process for the preparation of 5-substituted 4-amino-2-methylpyrimidines of the formula (I) wherein R is CONH2 or CN, and of acid addition salts thereof, characterized in that a compound of formula H2N CH = C(R) CN (II) is reacted with acetimidic acid methyl ester or an acid addition salt thereof and that, if desired, a compound of formula (I) is transferred into an acid addition salt, and the transformation of a compound of formula (Il) wherein R is CONH2 into a compound of formula (Il) wherein R is CN by treatment with POCI3.

Process for producing dialkyl aminoacrylonitrile

A process for producing a dialkyl aminoacrylonitrile by treating dimethylaminopropionitrile with a hydrogen acceptor in the presence of a dehydrogenation catalyst. The dialkylaminoacrylonitrile thus produced is converted to aminomethylene malonitrile, a known intermediate for thiamine.