672300-79-7Relevant articles and documents
Retention of chirality of 5-membered alicyclic α-amino acids bearing N-(2-phenyl)benzoyl group in photoinduced decarboxylative intermolecular radical addition to acrylonitrile
Ozaki, Yui,Yamada, Tomoaki,Mizuno, Taisei,Osaka, Kazuyuki,Yamawaki, Mugen,Maeda, Hajime,Morita, Toshio,Yoshimi, Yasuharu
, (2019/08/08)
Photoinduced decarboxylative radical additions of 5-membered alicyclic α-amino acids bearing a (2-phenyl)benzoyl protective group to acrylonitrile under mild organic photoredox catalysis conditions furnished γ-amino acid derivatives with high retention of chirality via the memory of chirality (MOC) strategy. The retention of chirality in the photoinduced decarboxylation was strongly dependent on the structure of the alicyclic α-amino acids and alkenes. To the best of our knowledge, this is the first example of the decarboxylative intermolecular radical addition to alkenes with retention of chirality at the position of radical generation using the MOC strategy.
AMIDE DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS
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Page 17; 20, (2008/06/13)
The present invention relates to novel amide derivatives useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of bone metabolic diseases, diseases resp