67257-68-5

Usage

Uses

Used in Recreational Drug Industry:
Ethanone, 1-(3,4-dimethoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)is used as a psychoactive stimulant for recreational purposes. It is sought after for its ability to induce stimulating effects, but it is important to note that its use can lead to serious health risks and legal consequences.

Upstream product

• 4687-37-0 ethyl 3,4-dimethoxybenzoylacetate 
• 20297-37-4 1-methyl-2-pyrrolidinecarbonitrile 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 68078-09-1 N-methylproline 
• 10441-57-3 1-methyl-pyrrolidine-2-thione 
• 1835-02-5 2-Bromo-1-(3,4-dimethoxyphenyl)ethanone 
• 114883-82-8 N-methyl-D-proline methyl ester 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 94882-50-5 1-methyl-2-veratroylmethylene-pyrrolidine 
• 186581-53-3 diazomethane 
• 126262-24-6 (-)-phyllostone 

Relevant academic research and scientific papers

Biomimetic Approach toward the Total Synthesis of rac-2-(Acylmethylene)pyrrolidine Alkaloids

2-(Acylmethylene)pyrrolidine derivatives were synthesized via intermolecular decarbonylative Mannich reaction from various methyl ketones and 1-alkyl-1-pyrroliniums, generated in situ from 1-alkylprolines. This approach mimics the biosynthetic pathway and provides a direct access to a series of 2-(acylmethylene)pyrrolidine alkaloids, including hygrine, N-methylruspolinone, dehydrodarlinine, and ruspolinone.

Alkaloids of Cryptocarya phyllostemon

The known alkaloids (-)-antofine (1), dehydroantofine (5), (-)-cryptowoline (6), (-)-cryptowolidine (7), and (-)-cryptowolinol (8), were isolated from the New Caledonian lauraceous plant Cryptocarya phyllostemon, together with five new bases : two secophenanthroindolizidines, (-)-phyllostemine (2) and (-)-phyllosteminine (3), one pyrrolidinylacetophenone, (-)-phyllostone (4), and two quaternary tetrahydrobenzylisoquinolines, (+)-phyllocryptine (9) and (+)-phyllocryptonine (10).Chemical and spectroscopic methods were used for identification and structural investigation.A synthesis of phyllocryptonine has permitted its stereostructure to be determined.

THE APPLICATION OF THE SULPHIDE CONTRACTION TO THE SYNTHESIS OF SOME SIMPLE PYRROLIDINE ALKALOIDS

The alkaloids (+/-)-hygrine, (+/-)-dehydrodarlinine, (+/-)-dehydrodarlingianine, and (+/-)-N-methylruspolinone have been synthesised by selective reduction of vinylogous amides formed by sulphide contraction of the salts prepared by reaction of N-methyl-2

NOVEL APPLICATIONS OF THE MODIFIED POLONOVSKII REACTION - IV. PREPARATION OF (+/-)-HYGRINE AND (+/-)-N-METHYLRUSPOLINONE

Preparation of (+/-)-hygrine 5 and (+/-)-N-methylruspolinone 6 via N-methyl-2-cyanopyrrolidine 1 is described.