67295-44-7

Upstream product

• 79754-49-7 3-hydroxy-3,4-bis-(4-methoxy-phenyl)-butyric acid ethyl ester 
• 67295-37-8 3,4-bis-p-methoxyphenylbutanoic acid 

Downstream Products

• 79813-32-4 (+/-)-di-O-methylsequirin D 
• 79813-33-5 (+/-)-sequirin D 
• 79754-58-8 7-hydroxy-4-p-hydroxybenzyl-3,4-dihydronaphthalen-1(2H)-one 
• 79754-54-4 7-hydroxy-4-p-hydroxybenzyl-1,2,3,4-tetrahydro-1-naphthol 
• 79754-56-6 7-methoxy-4-p-methoxybenzyl-3,4-dihydronaphthalen-1(2H)-one 
• 79754-57-7 7-methoxy-4-p-methoxybenzyl-1,2,3,4-tetrahydro-1-naphthol 
• 79754-48-6 4,5-bis-(p-methoxyphenyl)pentanoic acid 

Relevant academic research and scientific papers

Synthesis of 5-p-Hydroxybenzyl-5,6-dihydro-2-naphthol, (+/-)-Sequirin D

A high-yield six-step synthesis of sequirin D (1a), a naturally occurring norlignan, is described.Michael addition of deoxyanisoin (2) to acrylonitrile gives a ketonitrile (3), which on Wolff-Kishner reduction is reduced and hydrolysed in situ to 4,5-bis-