67295-37-8

Upstream product

• 120-44-5 1,4-di(4-methoxyphenyl)ethanone 
• 105-36-2 ethyl bromoacetate 
• 1226-42-2 1,2-bis(4-methoxyphenyl)-1,2-ethanedione 
• 696-62-8 para-iodoanisole 
• 79754-49-7 3-hydroxy-3,4-bis-(4-methoxy-phenyl)-butyric acid ethyl ester 

Downstream Products

• 67295-44-7 3,4-Bis-(4-methoxy-phenyl)-butyryl chloride 
• 79813-32-4 (+/-)-di-O-methylsequirin D 
• 79813-33-5 (+/-)-sequirin D 
• 79754-58-8 7-hydroxy-4-p-hydroxybenzyl-3,4-dihydronaphthalen-1(2H)-one 
• 79754-54-4 7-hydroxy-4-p-hydroxybenzyl-1,2,3,4-tetrahydro-1-naphthol 
• 79754-56-6 7-methoxy-4-p-methoxybenzyl-3,4-dihydronaphthalen-1(2H)-one 
• 79754-57-7 7-methoxy-4-p-methoxybenzyl-1,2,3,4-tetrahydro-1-naphthol 
• 79754-48-6 4,5-bis-(p-methoxyphenyl)pentanoic acid 

Relevant academic research and scientific papers

Three-component vicinal-diarylation of alkenes: Via direct transmetalation of arylboronic acids

Herein, we report three-component vicinal-diarylation of non-conjugated alkenes initiated by transmetalation of arylboronic acids, which provides complementary access to β,γ-diaryl carbonyl compounds. We have also screened a large number of chiral ligands for developing an enantioselective version of this reaction and obtained the preliminary results (up to 79: 21 e.r.). Notably, the methodology developed herein represents the first three component syn-vicinal-dicarbofunctionalization of non-conjugated alkenes involving palladium catalysis.

Synthesis of 5-p-Hydroxybenzyl-5,6-dihydro-2-naphthol, (+/-)-Sequirin D

A high-yield six-step synthesis of sequirin D (1a), a naturally occurring norlignan, is described.Michael addition of deoxyanisoin (2) to acrylonitrile gives a ketonitrile (3), which on Wolff-Kishner reduction is reduced and hydrolysed in situ to 4,5-bis-