67375-00-2

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 20735-33-5 2-aminocyclopent-1-ene-1-carbodithioic acid 
• 75-15-0 carbon disulfide 
• 333-20-0 potassium thioacyanate 
• 10277-86-8 (R)-1-phenylethylamine hydrochloride 
• 24277-44-9 (1-isothiocyanato-ethyl)-benzene 
• 100-42-5 styrene 
• 618-36-0 rac-methylbenzylamine 

Downstream Products

• 67277-79-6 N,N'-di-(R)-α-phenylethylcarbodiimide 

Relevant academic research and scientific papers

MCM-41-TBD as a new, efficient, supported heterogeneous catalyst for the synthesis of thioureas

The preparation of thioureas, by reaction of carbon disulfide with primary amines, can be efficiently catalyzed, under heterogeneous conditions, by MCM-TBD as a new and reusable catalyst.

Thioureas and their cyclized derivatives: Synthesis, conformational analysis and antimicrobial evaluation

Several single enantiomer thioureas have been synthesized and have been converted to their cyclic derivatives: 2-imino-thiazolidin-4-ones. The conformations of the thioureas have been determined in solution and in the solid state. In solution; an intercon

Synthesis of phosphaguanidines by hydrophosphination of carbodiimides with phosphine boranes

The direct addition of anionic secondary phosphine boranes to carbodiimides yields both chiral and achiral phosphaguanidine boranes under ambient temperature conditions. An analogous preparation of menthol-derived phosphinite boranes is also described. These products can be deborinated to give the corresponding phosphines, and subsequently oxidized to give phosphine oxides. The robustness of this method was further demonstrated in the synthesis of structurally novel cyclic phosphaguanidines. (Chemical Equation Presented).

Solvent-free synthesis of chiral N,N′-disubstituted thioureas by 'just mixing' the reagents

The synthesis of new chiral thioureas 3a-f by using the ecofriendly solvent-free and microwave-assisted approaches is reported and, unexpectedly, in the former method by just mixing the starting materials the products are instantaneously obtained. The crystal structures for 3b, 3c and 3e are also reported.

A convenient method for the preparation of primary and symmetrical N,N'-disubstituted thioureas

A convenient process for the preparation of both primary thioureas 2 and symmetrical N,N'-disubstituted thioureas 6 based on the condensation of amine hydrohalides 5 with potassium thiocyanate has been developed. This approach tolerates sterically bulky primary amine substrates (both chiral and achiral), and the products can usually be isolated by a simple filtration of the reaction mixture. This method is an especially attractive alternative for the synthesis of thioureas when the corresponding isothiocyanates are unavailable, or difficult to prepare. It is also worth noting that a wide variety of amine hydrohalides, which are used in this procedure, are commercially available.

Two new chiral equivalents of H2S: A thio- and a dithiocarboxylic acid

The syntheses of the two new chiral mercapto derivatives (R)-2-[N-(1-phenylethyl)-amino]-1-cyclopentenedithiocarboxylic acid, 5, and (1S,4R)-1-(4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane)thiocarbox ylic acid, 9, are described through easy transformations in good yields.