34006-70-7Relevant articles and documents
Preparation method 1 and 2 - cyclohexanedione
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Paragraph 0048-0051; 0055-0058; 0060-0063; 0065-0068; 0075, (2021/11/10)
The invention belongs to the technical field of chemical synthesis and particularly relates to a preparation method of 1-2 - cyclohexanedione. The invention provides 1-2 - Cyclohexanedione preparation method which comprises the following steps: cyclohexanone. The bromo reagent, the basic catalyst and the polar organic solvent are mixed for bromination reaction to obtain 2, 6 - dibromocyclohexanone. The mixture of 2, 6 - dibromocyclohexanone, inorganic base and polar solvent is subjected to hydrolysis reaction to obtain the 1, 2 -cyclohexanedione. To the preparation method, cyclohexanone and bromination reagent are taken as raw materials, 1 and 2 - cyclohexanedione with high yield and high purity can be prepared by sequentially conducting bromination reaction and hydrolysis reaction, and the preparation method provided by the invention is simple and easy to obtain and suitable for industrial production.
Synthesis of various cyclopropyl methyl bromide and its derivatives from ketones and/or aldehydes and some β-dicarbonyl compounds in the presence of BrCN and Et3N
Gholizadeh, Saeed,Safa, Kazem D.,Noroozi Pesyan, Nader
, p. 1239 - 1253 (2019/04/27)
The ultimate goal in this paper has been developed for the synthesis of structurally various bromomethyl cyclopropane via an α-bromoketone and/or aldehydes with ethyl cyanoacetate or malononitrile and cyanogen bromide (BrCN) in the presence of Et3N to give products in excellent yields within about 3?s. All structures were characterized by IR, 1H-NMR, 13C-NMR, and Mass spectroscopy techniques. The reaction mechanism was discussed.
Reactivity of aminophosphonic acids. Oxidative dephosphonylation of 1-aminoalkylphosphonic acids by aqueous halogens
Drabowicz, Józef,Jordan, Frank,Kudzin, Marcin H.,Kudzin, Zbigniew H.,Stevens, Christian V.,Urbaniak, Pawe?
, p. 2308 - 2317 (2016/02/09)
The reactions of 1-aminoalkylphosphonic acids with bromine-water, chlorine-water and iodine-water were investigated. The formation of phosphoric(v) acid, as a result of a halogen-promoted cleavage of the Cα-P bond, accompanied by nitrogen release, was observed. The dephosphonylation of 1-aminoalkylphosphonic acids was found to occur quantitatively. In the reactions of 1-aminoalkylphosphonic acids with other halogen-water reagents investigated by 31P NMR, scission of the Cα-P bond was also observed, the reaction rates being comparable for bromine and chlorine, but much slower for iodine.
Aryloxy cyclohexyl imidazoles: A novel class of antileishmanial agents
Srinivas, Nagarapu,Palne, Shraddha,Nishi,Gupta, Suman,Bhandari, Kalpana
scheme or table, p. 324 - 327 (2011/02/28)
Thirteen novel aryloxy cyclohexane-based mono and bis imidazoles were synthesized and evaluated in vitro as antileishmanials against Leishmania donovani and cytotoxicity assessed. These compounds were better than the existing drugs, sodium stibogluconate
Photochemical α-bromination of ketones using N-bromosuccinimide: a simple, mild and efficient method
Arbuj, Sudhir S.,Waghmode, Suresh B.,Ramaswamy
, p. 1411 - 1415 (2007/10/03)
Aromatic and aliphatic carbonyl compounds undergo facile bromination with N-bromosuccinimide under UV-vis irradiation to give the corresponding α-brominated ketones in good yields, at low temperatures (30 °C), without any catalyst, catalyst support or radical initiator and within a short time.
TMS·OTf-Catalyzed α-bromination of carbonyl compounds by N-bromosuccinimide
Guha, Samar Kumar,Wu, Bo,Kim, Beom Soo,Baik, Woonphil,Koo, Sangho
, p. 291 - 293 (2007/10/03)
Various carbonyl compounds undergo α-bromination reaction under a mild and practical condition utilizing N-bromosuccinimide (NBS), catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS·OTf). This method is also effective for the side-chain bromination of heteroaromatic carbonyl compounds without the ring brominations.
A mild and efficient procedure for α-bromination of ketones using N-bromosuccinimide catalysed by ammonium acetate
Tanemura, Kiyoshi,Suzuki, Tsuneo,Nishida, Yoko,Satsumabayashi, Koko,Horaguchi, Takaaki
, p. 470 - 471 (2007/10/03)
Cyclic ketones reacted with N-bromosuccinimide (NBS) catalysed by NH 4OAc in Et2O at 25°C to give the corresponding α-brominated ketones in good yields, while acyclic ketones were efficiently brominated in CCl4 at 80°C.
Dichotomous reactivity of PCl5 and PBr5 toward cyclic ketones: A one-step preparation of 1,1,2-trichlorocycloalkanes
Brown,Chronister,Watkins,Mazzaccaro,Rajski,Fountain,McKay,Gibson
, p. 485 - 501 (2007/10/02)
Small-ring cyclic ketones react with excess PCl5 in CCl4 (reflux, 1-3 d) to give the corresponding 1,1,2-trichlorocycloalkanes, but react with PBr5 to give ketones brominated in the α-positions.
SELECTIVE MONOBROMINATION OF KETONES BY BIS(DIMETHYLACETAMIDE)HYDROGEN TRIBROMIDE
Rodygin, M. Yu.,Mikhailov, V. A.,Savelova, V. A.
, p. 881 - 887 (2007/10/02)
A unified procedure for the α-monobromination of ketones by bis(dimethylacetamide)hydrogen tribromide in methanol is proposed.Methyl aryl ketones with donating and moderately accepting substituents in the ring readily enter into the reaction. 1-Bromo ketones are mostly formed during the bromination of methyl alkyl ketones.
Oxybromination Catalysed by the Heteropolyanion Compound H5PMo10V2O40 in an Organic Medium: Selective para-Bromination of Phenol
Neumann, Ronny,Assael, Igal
, p. 1285 - 1287 (2007/10/02)
Selective bromination of phenol and its derivatives and the bromination of ketones and alkenes have been achieved by oxybromination at ambient conditions catalysed by the mixed addenda heteropolyanion compound H5PMo10V2O40, which is dissolved in a nonpolar chlorohydrocarbon solvent by complexation with tetraglyme.
