67468-65-9

Basic information

• Product Name: 4-BENZYL-BENZALDEHYDE
• Synonyms: 4-(phenylmethyl)-benzaldehyd;p-benzyl-benzaldehyd;4-BENZYL-BENZALDEHYDE;p-Benzylbenzaldehyde
• CAS NO: 67468-65-9
• Molecular Formula: C₁₄H₁₂O
• Molecular Weight: 196.24
• EINECS: 200-589-5
• Product Categories: pharmacetical
• Mol File: 67468-65-9.mol
• Article Data: 32

Chemical Properties

• Boiling Point: 330.8 °C at 760 mmHg
• Flash Point: 175.4 °C
• Appearance: /
• Density: 1.087 g/cm³
• Vapor Pressure: 0.000163mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: Refrigerator, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-BENZYL-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BENZYL-BENZALDEHYDE(67468-65-9)
• EPA Substance Registry System: 4-BENZYL-BENZALDEHYDE(67468-65-9)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• RTECS: CU4770000
• Hazardous Substances Data: 67468-65-9(Hazardous Substances Data)

Usage

Uses

4-benzylbenzaldehyde is a useful reactant for the synthesis of benzoyl-benzylidenecyclohexanone analogs as a dual inhibitor for acetylcholinesterase and butyrylcholinesterase.

InChI:InChI=1/C14H12O/c15-11-14-8-6-13(7-9-14)10-12-4-2-1-3-5-12/h1-9,11H,10H2

Upstream product

• 100-97-0 hexamethylenetetramine 
• 14297-39-3 4-benzylbenzyl chloride 
• 35714-20-6 4-benzylbenzyl alcohol 
• 79-15-2 N-bromoacetamide 
• 201230-82-2 carbon monoxide 
• 101-81-5 Diphenylmethane 
• 1539-57-7 diethyl 2,6-dimethyl-4-benzyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 1122-91-4 4-bromo-benzaldehyde 
• 100-39-0 benzyl bromide 
• 28144-70-9 anthranilic acid amide 
• 23450-31-9 4-benzylbenzonitrile 
• 100-52-7 benzaldehyde 
• 100-51-6 benzyl alcohol 
• 100-53-8 phenylmethanethiol 

Downstream Products

• 102078-69-3 (4-benzyl-benzyliden)-aniline 
• 90811-81-7 4-benzyl-trans-chalcone 
• 101596-45-6 (E)-4-(4-benzylphenyl)but-3-en-2-one 
• 121816-53-3 1t,5t-bis-(4-benzyl-phenyl)-penta-1,4-dien-3-one 
• 102876-52-8 (4-benzyl-phenyl)-bis-(4-hydroxy-phenyl)-methane 
• 262436-69-1 5-(4-benzyl-benzylidene)-2-thioxo-thiazolidin-4-one 
• 262425-95-6 1-[(1E)-3-chloro-1-propenyl]-4-(phenylmethyl)benzene 
• 193819-67-9 3-(4-benzyl-phenyl)-propionic acid methyl ester 
• 1026893-20-8 3-(4-benzyl-phenyl)-2,2-dichloro-cyclobutanone 
• 262425-94-5 1-[1-oxo-3-[4-(phenylmethyl)phenyl]propyl]pyrrolidine 
• 1159113-30-0 (4aS,4bR,5S,6aS,6bS,8R,9aR,10aS,10bS,12S)-8-(4-benzylphenyl)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one 
• 1361005-65-3 1-(4-benzylphenyl)propan-1-ol 

Relevant articles and documents

Nickel-Catalyzed Reductive Cross-Coupling of Benzylic Sulfonium Salts with Aryl Iodides

A nickel-catalyzed cross-electrophile coupling of benzylic sulfonium salts with aryl iodides has been developed, providing direct access to diarylalkanes from readily available and stable coupling partners. Preliminary mechanistic studies suggest that the C-S bond cleavage proceeds through a single-electron transfer process to generate a benzylic radical.

Desulfurative Ni-Catalyzed Reductive Cross-Coupling of Benzyl Mercaptans/Mercaptoacetates with Aryl Halides

The C-S activation and sulfur removal from native thiols is challenging, which limits their application as feedstock materials in organic synthesis despite their natural abundance. Herein, we introduce a per-/polyfluoroaryl moiety, which serves as a redox-active scaffold, into sp3-hybridized thiols to activate the C-S bond. Using a Ni catalyst with MgBr2 as an additive, the S group can be removed to yield an aliphatic radical that can react with an aryl halide in a reductive cross-coupling.

Photoredox Heterobimetallic Dual Catalysis Using Engineered Covalent Organic Frameworks

The functionalization of an imine-based layered covalent organic framework (COF), containing phenanthroline units as ligands, has allowed the obtention of a heterobimetallated material. Photoactive Ir and Ni fragments were immobilized within the porous structure of the COF, enabling heterogeneous light-mediated Csp3-Csp2cross-couplings. As radical precursors, potassium benzyl- and alkoxy-trifluoroborates, organic silicates, and proline derivatives were employed, which brings out the good versatility ofIr,Ni@Phen-COF. Moreover, in all the studied cases, an enhanced activity and stability have been observed in comparison with analogous homogenous systems.