674787-19-0Relevant academic research and scientific papers
Rational design and synthesis of selective BACE-1 inhibitors
Brady, Stephen F.,Singh, Satendra,Crouthamel, Ming-Chih,Holloway, M. Katharine,Coburn, Craig A.,Garsky, Victor M.,Bogusky, Michael,Pennington, Michael W.,Vacca, Joseph P.,Hazuda, Daria,Lai, Ming-Tain
, p. 601 - 604 (2004)
An effective approach for enhancing the selectivity of β-site amyloid precursor protein cleaving enzyme (BACE 1) inhibitors is developed based on the unique features of the S1′ pocket of the enzyme. A series of low molecular weight (600) compounds were s
