Bioorganic and Medicinal Chemistry Letters p. 601 - 604 (2004)
Update date:2022-08-02
Topics:
Brady, Stephen F.
Singh, Satendra
Crouthamel, Ming-Chih
Holloway, M. Katharine
Coburn, Craig A.
Garsky, Victor M.
Bogusky, Michael
Pennington, Michael W.
Vacca, Joseph P.
Hazuda, Daria
Lai, Ming-Tain
An effective approach for enhancing the selectivity of β-site amyloid precursor protein cleaving enzyme (BACE 1) inhibitors is developed based on the unique features of the S1′ pocket of the enzyme. A series of low molecular weight (<600) compounds were s
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(2004)
