67490-38-4Relevant articles and documents
Catalyst-free multicomponent Strecker reaction in acetonitrile
Martínez, Ricardo,Ramón, Diego J.,Yus, Miguel
, p. 8471 - 8474 (2005)
The multicomponent Strecker reaction using trimethylsilyl cyanide was accomplished without any type of Lewis acid. The reaction performed in acetonitrile as solvent gave excellent results for any class of aldehydes (aromatic or aliphatic), as well as amines (aromatic or aliphatic). In many cases, α-aminonitrile product was isolated pure after the usual work-up, with quantitative chemical yields. A comparison between different solvents indicated that acetonitrile is the best choice. The rate comparison using different Lewis acids showed that all of them catalyzed the reaction in a similar extent, the difference with the acid Lewis-free being minimal.
Synthesis of novel magnetic nanoparticles with urea or urethane moieties: Applications as catalysts in the Strecker synthesis of α-aminonitriles
Baghery, Saeed,Zolfigol, Mohammad Ali,Schirhagl, Romana,Hasani, Masoumeh,Stuart, Marc C.A.,Nagl, Andreas
, (2017/10/03)
Four novel magnetic nanoparticle catalysts with urea or urethane moieties are reported. The silica-coated magnetic nanoparticles were simply functionalized via addition of 3-(triethoxysilyl)propylisocyanate (TESPIC), amine or amino alcohol. TESPIC with dual labile functional groups was used as a suitable precursor for the synthesis of urethane-based catalysts. The newly synthesized catalysts were fully characterized using a variety of techniques. These functionalized magnetic nanoparticles were used as reusable catalysts in the Strecker synthesis of α-aminonitrile derivatives under solvent-free conditions at 50?°C.
Zn(OAc)2·2H2O-catalyzed one-pot efficient synthesis of α-amino nitriles
Reddy, V. Venkata Rami,Saritha,Ramu,Varala, Ravi,Jayashree
, p. 7439 - 7442 (2015/04/22)
A mild, efficient one-pot three component strecker reaction involving electronically and structurally divergent aldehydes, amines and trimethly silyl cyanide in chloroform as solvent at room temperature was accomplished in moderate to excellent yields using an inexpensive and readily available catalyst, Zn(OAc)2.2H2O.
