675605-72-8Relevant articles and documents
Primary Sulfonamide Functionalization via Sulfonyl Pyrroles: Seeing the N?Ts Bond in a Different Light
Ozaki, Tomoya,Yorimitsu, Hideki,Perry, Gregory J. P.
supporting information, p. 15387 - 15391 (2021/10/04)
Despite common occurrence in molecules of value, methods for transforming sulfonamides are distinctly lacking. Here we introduce easy-to-access sulfonyl pyrroles as synthetic linchpins for sulfonamide functionalization. The versatility of the sulfonyl pyrrole unit is shown by generating a variety of products through chemical, electrochemical and photochemical pathways. Preliminary results on the direct functionalization of primary sulfonamides are also provided, which may lead to new modes of activation.
Development of celecoxib-derived antifungals for crop protection
Liu, Xiuxiu,Ma, Yihui,Sun, Xianglong,Yang, Jun,Yang, Lirong
supporting information, (2020/02/27)
Selective COX-2 inhibitor celecoxib was found directly inhibiting the growth of tested phytopathogenic fungi with the inhibitory rate ranging from 30 to 40% at 100 μg/ml. Lead optimization of celecoxib led to the identification of compound 12 among its derivatives as the most active antifungal candidate. The antifungal effect of compound 12 was supposed to be independent of COX-2 inhibition. Transcriptome profiling analysis of Fusarium graminearium (PH-1) treated with compound 12 brought about 406 up-regulated and 572 down-regulated differentially express genes (DEGs) respectively.
Discovery of synthetic small molecules that enhance the number of stomata: C-H functionalization chemistry for plant biology
Ziadi, Asraa,Uchida, Naoyuki,Kato, Hiroe,Hisamatsu, Rina,Sato, Ayato,Hagihara, Shinya,Itami, Kenichiro,Torii, Keiko U.
, p. 9632 - 9635 (2017/09/01)
The increasing climate changes and global warming are leading to colossal agricultural problems such as abatement of food production and quality. As stomatal development is considered to play a key role in crop plant productivity and water-use efficiency,
