67564-48-1Relevant academic research and scientific papers
A convenient method for the synthesis of N-protected 1-aminoalkylphosphonate mixed monothioesters and dithioesters
Xu,Wei
, p. 1489 - 1497 (2007/10/03)
A series of N-protected 1-aminoalkylphosphonate mixed monothioesters and dithioesters were synthesized using one-pot reactions of benzyl carbamate, aldehydes and alkoxyphosphine dichlorides or alkylthiophosphine dichloride, followed by alcoholysis with thiol or alcohols in the presence of triethylamine.
A modified method for synthesis of alkyl hydrogen α-(benzyloxycarbonylamino)-benzylphosphonates
Dai, Qing,Chen, Ruyu
, p. 3341 - 3347 (2007/10/03)
A series of alkyl hydrogen α-(benzyloxycarbonylamino)benzylphosphosphonates are prepared from benzyl carbamate, substituted benzaldehydes and alkoxydichlorophosphine in acetyl chloride and subsequent hydrolysis. Compared with the previous methods, the reaction avoids producing the corresponding diesters and thus improves the yields of the products.
Studies on organophosphorus compounds XLVII: Acetyl chloride - A versatile reagent for the synthesis of 1-aminoalkyl- and amino(aryl)methylphosphonic acid derivatives
Yuan,Chen,Wang
, p. 490 - 493 (2007/10/02)
Acetyl chloride is used successfully in the synthesis of 1-aminoalkyl- and amino(aryl)methylphosphonic acid derivatives by a three-component condensation reaction involving diethyl phosphoramidate, aldehydes and diphenyl phosphite. Furthermore, in the reaction of benzyl carbamate, aldehydes and phosphorus(III) chloride, acetyl chloride facilates the formation of alkyl hydrogen 1-(benzyloxycahronylamino)alkylphosphonates or aryl(benzyloxycarbonylamino)methylphosphonates, key intermediates in the synthesis of phosphonopeptide with a P-N bond. In comparison with other methods, the present variation affords wider scope of application including the use of some aliphatic aldehydes, fair yields and mild reaction conditions.
Studies on Organophosphorus Compounds; XLI. A Convenient Synthesis of Alkyl Hydrogen α-(Benzyloxycarbonylamino)benzylphosphonates
Yuan, Chengye,Wang, Guohong
, p. 256 - 258 (2007/10/02)
Alkyl hydrogen α-(benzyloxycarbonylamino)benzylphosphonates are prepared from substituted benzaldehydes, benzyl carbamate, and phosphorus(III) chloride in acetic acid containing thionyl chloride and subsequent alcoholysis.The reactions proceed smoothly at
A Convenient Synthesis of Alkyl Hydrogen 1-(Benzyloxycarbonylamino)-alkanephosphonates
Hoffmann, Maria
, p. 557 - 559 (2007/10/02)
Alkyl hydrogen 1-(benzyloxycarbonylamino)-alkanephosphonates are prepared by condensation of 1-(benzyloxycarbonylamino)-alkanephosphonic acids with primary and secondary alcohols in the presence of thionyl chloride in dimethylformamide.
AMINOPHOSPHONIC ACIDS. PART XV. 2,2,2-TRICHLOROETHYL AS A PROTECTIVE OF PHOSPHONIC GROUP IN N-ACYL-1-AMINOALKANEPHOSPHONIC ACIDS
Szewczyk, Jerzy,Wasielewski, Czeslaw
, p. 1985 - 1994 (2007/10/02)
Methods of synthesizing N-acyl-1-aminoalkanephosphonic acid 2,2,2-trichloroethyl monoesters and alkyl-2,2,2-trichloroethyl diester were described.Various methods of selective non-hydrolytic cleavage of phosphonic and amino groups protections were investig
