67580-78-3Relevant academic research and scientific papers
The amide C-N bond of isatins as the directing group and the internal oxidant in Ru-catalyzed C-H activation and annulation reactions: Access to 8-amido isocoumarins
Kaishap, Partha Pratim,Sarma, Bipul,Gogoi, Sanjib
, p. 9809 - 9812 (2016)
The N-O, N-N and O-O bonds are the frequently used internally oxidative directing groups used in various redox-neutral coupling reactions. The sole use of the C-N bond as the oxidizing directing group was reported recently by Li X. and co-workers for the Rh(iii)-catalyzed C-H activation of phenacyl ammonium salts. Herein, we report the use of the amide C-N bond of isatins as the oxidizing directing group for the Ru(ii)-catalyzed redox-neutral C-H activation and annulation reactions with alkynes which afford 8-amido isocoumarins. The reaction also features excellent regioselectivity with alkyl aryl substituted alkynes.
Copper-Catalyzed C–N, C–O Coupling Reaction of Arylglyoxylic Acids with Isatins
Prakash, Rashmi,Gogoi, Sanjib
supporting information, p. 3046 - 3049 (2016/10/09)
The copper(II)-catalyzed decarboxylative coupling reactions of arylglyoxylic acids with isatins afford 4H-benzo[d][1,3]oxazin-4-ones via decarbonylation and concurrent C–N, C–O bond formation. (Figure presented.).
