6760-22-1

Basic information

• Product Name: 2-METHYLQUINOLINE-4-CARBOXALDEHYDE
• Synonyms: 2-METHYLQUINOLINE-4-CARBOXALDEHYDE
• CAS NO: 6760-22-1
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.19526
• Mol File: 6760-22-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 141 °C
• Boiling Point: 314.53°C at 760 mmHg
• Flash Point: 152.01°C
• Appearance: /
• Density: 1.183g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.665
• PKA: 3.77±0.50(Predicted)
• CAS DataBase Reference: 2-METHYLQUINOLINE-4-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLQUINOLINE-4-CARBOXALDEHYDE(6760-22-1)
• EPA Substance Registry System: 2-METHYLQUINOLINE-4-CARBOXALDEHYDE(6760-22-1)

Safety Data

• Hazardous Substances Data: 6760-22-1(Hazardous Substances Data)

Usage

General Description

2-Methylquinoline-4-carboxaldehyde is a chemical compound derived from quinoline, a naturally occurring heterocyclic aromatic compound. It is used in various industrial processes, including as a building block for the synthesis of pharmaceuticals and other organic compounds. This chemical is often employed as a reagent in organic synthesis and as a precursor for the production of dyes, perfumes, and flavoring agents. Its unique chemical structure and versatile reactivity make it a valuable tool in the development of new materials and compounds for a wide range of applications. However, it is important to handle and use this chemical with caution, as it can be harmful if not handled properly.

InChI:InChI=1/C11H9NO/c1-8-6-9(7-13)10-4-2-3-5-11(10)12-8/h2-7H,1H3

Upstream product

• 55625-40-6 methyl 2-methylquinoline-4-carboxylate 
• 7120-26-5 ethyl 2-methylquinoline-4-carboxylate 
• 91-56-5 indole-2,3-dione 
• 634-38-8 2-methylquinoline-4-carboxylic acid 
• 91-63-4 2-methylquinoline 
• 20461-86-3 2,2-diethoxy acetic acid 
• 40105-25-7 2-methyl-4-(1,3,5-trioxan-2-yl)quinoline 
• 110-88-3 1,3,5-Trioxan 
• 50488-44-3 4-Bromo-2-methylquinoline 
• 4939-28-0 4-(hydroxymethyl)-2-methylquinoline 

Relevant articles and documents

Hydroxymethylation of quinolinesviairon promoted oxidative C-H functionalization: synthesis of arsindoline-A and its derivatives

Herein, we report a mild and efficient hydroxymethylation of quinolinesviaan iron promoted cross-dehydrogenative coupling reaction under external acid free conditions. Various hydroxyalkyl substituted quinolines were achieved in excellent yields with well tolerated functional groups. Importantly, a few of the hydroxylmethylated quinolines were further transformed into respective aldehydes, and were successfully utilized for the synthesis of alkaloid arsindoline-A and its derivatives.

Quinoline substituted chalcone compound as well as preparation method and application thereof

The invention discloses a novel quinoline substituted chalcone compound as well as pharmaceutically acceptable salts and a preparation method thereof. The invention further discloses a pharmaceuticalcomposition which comprises a therapeutically effective amount of the novel quinoline substituted chalcone compound and/or the pharmaceutically acceptable salts and a pharmaceutically acceptable carrier. The invention further discloses a tubulin inhibitor which comprises the novel quinoline substituted chalcone compound and/or the pharmaceutically acceptable salts. The invention further disclosesapplication of the novel quinoline substituted chalcone compound and/or the pharmaceutically acceptable salts in preparing drugs for treating but not limited to colon cancer, leukemia, liver cancer, breast cancer and other diseases. The compound in the application shows excellent anti-tumor activity, and has more stable metabolic properties and better druggability prospect.

Photoredox-Catalyzed Decarboxylative C-H Acylation of Heteroarenes

A mild, environmentally friendly, and regioselective acylation of heterocycles with inexpensive carboxylic acids is reported via photoredox catalysis. The strategy is highlighted with good functional group tolerance and substrate scope which could rapidly