10
20. Speck, K.; Wildermuth, R.; Magauer, T., Angew. Chem., Int.
Ed. 2016, 55, 14131–14135.
21. Speck, K.; Magauer, T., Chem. Eur. J. 2017, 23, 1157–1165.
1H), 2.28 (d, J = 18.1 Hz, 1H), 2.20 – 2.08 (m, 2H), 2.06 – 2.00
(m, 1H), 1.78 – 1.70 (m, 1H), 1.66 – 1.59 (m, 1H), 1.49 – 1.44
(m, 1H), 1.30 – 1.24 (m, 1H), 1.02 (d, J = 6.9 Hz, 3H), 0.99 (d, J
= 6.9 Hz, 3H), 0.78 (s, 3H), 0.74 (d, J = 6.8 Hz, 3H). 13C NMR
(151 MHz, CDCl3) δ = 169.3, 158.7, 148.9, 143.4, 137.7, 132.0,
131.6, 128.8, 128.4, 127.6, 121.9, 113.7, 96.1, 95.2, 56.1, 47.5,
46.7, 37.7, 32.1, 31.6, 30.5, 29.3, 28.0, 27.1, 22.4, 22.2, 20.7,
16.1, 15.8. IR (Diamond-ATR, neat): ꢋꢆꢌꢍꢎ = 2959, 1691, 1609,
1473, 1365, 1324, 1108, 910, 732, 700 cm–1. HRMS (EI) calcd.
for C31H37NO3 [M]+: 471.2773; found: 471.2775.
ACCEPTED MANUSCRIPT
22. (a) Yoon, T.; Danishefsky, S. J.; de Gala, S., Angew. Chem., Int.
Ed. 1994, 33, 853–855; (b) Buter, J.; Heijnen, D.; Wan, I. C.;
Bickelhaupt, F. M.; Young, D. C.; Otten, E.; Moody, D. B.;
Minnaard, A. J., J. Org. Chem. 2016, 81, 6686–6696.
23. Quintiliano, S. A. P.; Silva, L. F., Tetrahedron Lett. 2012, 53,
3808–3810.
24. (a) Ashburn, B. O.; Carter, R. G., J. Org. Chem. 2007, 72, 10220–
10223; (b) Dai, M.; Sarlah, D.; Yu, M.; Danishefsky, S. J.; Jones,
G. O.; Houk, K. N., J. Am. Chem. Soc. 2007, 129, 645–657; (c)
Yang, Z.-Q.; Geng, X.; Solit, D.; Pratilas, C. A.; Rosen, N.;
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Acknowledgments
25. CCDC 1811000 contains the supplementary crystallographic data
for phthalate 23. These data can be obtained free of charge from
The
Cambridge
Crystallographic
Data
Centre
via
T.M. acknowledges the German Research Foundation (Emmy
Noether Project MA5999/2-1) and the Funds of the Chemical
Industry (Sachkostenzuschuss and Dozentenpreis). We thank Dr.
Julius R. Reyes (LMU Munich) and Sofia Torres Venegas (LFU
Innsbruck) for helpful discussions.
26. CCDC 1810999 contains the supplementary crystallographic data
for phthalimide 28.
27. Giannis, A.; Sandhoff, K., Angew. Chem., Int. Ed. 1989, 28, 218–
220.
28. An overview about the screening conditions can be found in the
supplementary data.
29. CCDC 1811001 contains the supplementary crystallographic data
for isoindolinone 29.
30. Saito, S.; Ishikawa, T.; Kuroda, A.; Koga, K.; Moriwake, T.,
Tetrahedron 1992, 48, 4067–4086.
31. Yeung; Chein, R.-J.; Corey, E. J., J. Am. Chem. Soc. 2007, 129,
10346–10347.
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