676127-79-0

Upstream product

• 478912-57-1 (2S)-2-{[(5-fluoro-2-pyridinyl)amino]carbonyl}-1-pyrrolidine 
• 676127-78-9 C₁₄H₁₉NO₂ 
• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 676127-83-6 C₁₅H₂₃NO₅S 
• 676127-81-4 (2R)-2-(hydroxymethyl)-N-[(phenylmethyl)oxy]hexanamide 
• 676127-84-7 (3R)-3-butyl-1-[(phenylmethyl)oxy]-2-azetidinone 

Downstream Products

• 478913-92-7 (2S)-N-(5-fluoro-2-pyridinyl)-1-[(2R)-2-[formyl(phenylmethoxy)amino]methyl]-1-oxohexyl-2-pyrrolidinecarboxamide 
• 478913-91-6 (S)-1-{(R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoyl}-pyrrolidine-2-carboxylic acid (5-fluoro-1-oxy-pyridin-2-yl)-amide 
• 478913-93-8 (2S)-N-(5-fluoro-1-oxido-2-pyridinyl)-1-[(2R)-2-[[formyl(phenylmethoxy)amino]methyl]-1-oxohexyl]-2-pyrrolidinecarboxamide 

Relevant academic research and scientific papers

β-amino amides from β-lactams: Application to the formal synthesis of a peptide-deformylase inhibitor

A facile and a practical synthesis of peptide-deformylase inhibitor 1 is described using an acid-catalyzed aminolysis of β-lactam 12 with pyrrolidine 6 as the key transformation. In addition, simplified conditions for the conversion of a β-hydroxy acid to

PROCESS FOR PREPARING INTERMEDIATES

The present invention is directed to a process for preparing intermediates that are useful to prepare certain antibacterial N-formyl hydroxylamine compounds which are peptide deformylase inhibitors. The process makes use α β-lactam intermediate. Certain o