676127-84-7Relevant articles and documents
Peptide deformylase inhibitors
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, (2014/12/09)
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.
Synthesis and in vitro antibacterial activity of oxazolidine LBM-415 analogs as peptide deformylase inhibitors
Yu, Linliang,Zhou, Weicheng,Wang, Zhenyu
, p. 1541 - 1544 (2011/04/16)
The drug resistant bacteria pose a severe threat to human health. The increasing resistance of those pathogens to traditional antibacterial therapy renders the identification of new antibacterial agents with novel antibacterial mechanisms an urgent need.
β-amino amides from β-lactams: Application to the formal synthesis of a peptide-deformylase inhibitor
Jiang, Xinglong,Prasad, Kapa,Prashad, Mahavir,Slade, Joel,Repi?, Oljan,Blacklock, Thomas J.
, p. 3179 - 3181 (2008/02/13)
A facile and a practical synthesis of peptide-deformylase inhibitor 1 is described using an acid-catalyzed aminolysis of β-lactam 12 with pyrrolidine 6 as the key transformation. In addition, simplified conditions for the conversion of a β-hydroxy acid to