676127-81-4Relevant articles and documents
Peptide deformylase inhibitors
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, (2014/12/09)
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.
PEPTIDE DEFORMYLASE INHIBITORS
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, (2014/02/15)
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhi-bition of bacterial peptide deformylase (PDF) activity
Synthesis and in vitro antibacterial activity of oxazolidine LBM-415 analogs as peptide deformylase inhibitors
Yu, Linliang,Zhou, Weicheng,Wang, Zhenyu
scheme or table, p. 1541 - 1544 (2011/04/16)
The drug resistant bacteria pose a severe threat to human health. The increasing resistance of those pathogens to traditional antibacterial therapy renders the identification of new antibacterial agents with novel antibacterial mechanisms an urgent need.
β-amino amides from β-lactams: Application to the formal synthesis of a peptide-deformylase inhibitor
Jiang, Xinglong,Prasad, Kapa,Prashad, Mahavir,Slade, Joel,Repi?, Oljan,Blacklock, Thomas J.
, p. 3179 - 3181 (2008/02/13)
A facile and a practical synthesis of peptide-deformylase inhibitor 1 is described using an acid-catalyzed aminolysis of β-lactam 12 with pyrrolidine 6 as the key transformation. In addition, simplified conditions for the conversion of a β-hydroxy acid to
PROCESS FOR PREPARING INTERMEDIATES
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Page 24, (2008/06/13)
The present invention is directed to a process for preparing intermediates that are useful to prepare certain antibacterial N-formyl hydroxylamine compounds which are peptide deformylase inhibitors. The process makes use α β-lactam intermediate. Certain o
