676127-81-4

Basic information

• Product Name: Hexanamide, 2-(hydroxymethyl)-N-(phenylmethoxy)-, (2R)-
• CAS NO: 676127-81-4
• Molecular Formula: C14H21NO3
• Molecular Weight: 251.326
• Mol File: 676127-81-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Hexanamide, 2-(hydroxymethyl)-N-(phenylmethoxy)-, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Hexanamide, 2-(hydroxymethyl)-N-(phenylmethoxy)-, (2R)-(676127-81-4)
• EPA Substance Registry System: Hexanamide, 2-(hydroxymethyl)-N-(phenylmethoxy)-, (2R)-(676127-81-4)

Safety Data

• Hazardous Substances Data: 676127-81-4(Hazardous Substances Data)

Upstream product

• 2687-43-6 O-benzylhydoxylamine hydrochloride 
• 2612-26-2 2-butylpropane-1,3-diol 
• 58243-89-3 (±)-2-butyl-3-hydroxypropionic acid 
• 2985-32-2 butylmalonic acid monoethyl ester 
• 142-61-0 Hexanoyl chloride 
• 668485-39-0 (4S)-3-[(2R)-2-(hydroxymethyl)hexanoyl]-4-(phenylmethyl)-1,3-oxazolidin-2-one 
• 29601-98-7 N-benzylhydroxylamine hydrochloride 
• 143965-32-6 (4S)-3-hexanoyl-4-(phenylmethyl)-1,3-oxazolidin-2-one 

Downstream Products

• 301685-23-4 (2R)-2-({formyl[(phenylmethyl)oxy]amino}methyl)hexanoic acid 
• 234768-83-3 (2R)-2-({[(phenylmethyl)oxy]amino}methyl)hexanoic acid 
• 1281973-29-2 C₂₅H₃₁FN₄O₆ 
• 1101196-96-6 C₂₄H₂₉FN₄O₆ 
• 1101196-50-2 C₂₂H₃₂N₄O₆ 
• 1101196-49-9 C₂₂H₃₁ClN₄O₆ 
• 1101196-48-8 C₂₂H₃₁FN₄O₆ 
• 1101196-47-7 C₁₉H₂₇N₃O₆ 
• 1281973-30-5 C₁₈H₂₃F₂N₃O₅ 
• 1101196-45-5 C₁₈H₂₄FN₃O₅ 
• 1101196-95-5 C₂₅H₃₁FN₄O₅ 
• 1101196-90-0 C₃₀H₃₉ClN₄O₆ 
• 1101196-93-3 C₃₀H₃₉FN₄O₆ 
• 1101196-92-2 C₂₆H₃₂FN₃O₅ 

Relevant articles and documents

Peptide deformylase inhibitors

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.

Synthesis and in vitro antibacterial activity of oxazolidine LBM-415 analogs as peptide deformylase inhibitors

The drug resistant bacteria pose a severe threat to human health. The increasing resistance of those pathogens to traditional antibacterial therapy renders the identification of new antibacterial agents with novel antibacterial mechanisms an urgent need.

PROCESS FOR PREPARING INTERMEDIATES

The present invention is directed to a process for preparing intermediates that are useful to prepare certain antibacterial N-formyl hydroxylamine compounds which are peptide deformylase inhibitors. The process makes use α β-lactam intermediate. Certain o