478913-91-6Relevant academic research and scientific papers
Chemical process for the preparation of intermediates to obtain n-formyl hydroxy-lamine compounds
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Page/Page column 13-14, (2008/06/13)
Improved processes for preparing intermediates useful for preparing antibacterial N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl}-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, which have one or more of the following feat
β-amino amides from β-lactams: Application to the formal synthesis of a peptide-deformylase inhibitor
Jiang, Xinglong,Prasad, Kapa,Prashad, Mahavir,Slade, Joel,Repi?, Oljan,Blacklock, Thomas J.
, p. 3179 - 3181 (2008/02/13)
A facile and a practical synthesis of peptide-deformylase inhibitor 1 is described using an acid-catalyzed aminolysis of β-lactam 12 with pyrrolidine 6 as the key transformation. In addition, simplified conditions for the conversion of a β-hydroxy acid to
A practical enantioselective synthesis of a novel peptide deformylase inhibitor
Slade, Joel,Parker, David,Girgis, Michael,Mueller, Martin,Vivelo, James,Liu, Hui,Bajwa, Joginder,Chen, Guang-Pei,Carosi, Joseph,Lee, Paul,Chaudhary, Apurva,Wambser, Dana,Prasad, Kapa,Bracken, Kathryn,Dean, Karl,Boehnke, Helmut,Repic, Oljan,Blacklock, Thomas J.
, p. 78 - 93 (2012/12/21)
A practical synthesis of the peptide deformylase inhibitor LBM415,(2S)-N-(5-fluoro-1-oxido-2-pyridinyl)-1-[(2R)-2-[(formylhydroxyamino) methyl]-1-oxohexyl]-2-pyrrolidinecarboxamide, magnesium salt 11, is described. The key chiral intermediate, (2S)-N-(5-f
