676131-91-2

Basic information

• Product Name: ethyl 2-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]acetate
• Synonyms: ethyl 2-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]acetate
• CAS NO: 676131-91-2
• Molecular Weight: 394.211
• Mol File: 676131-91-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]acetate(676131-91-2)
• EPA Substance Registry System: ethyl 2-[5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]acetate(676131-91-2)

Safety Data

• Hazardous Substances Data: 676131-91-2(Hazardous Substances Data)

Upstream product

• 26488-93-7 N-(5-chloro-2-hydroxyphenyl)acetamide 
• 676131-85-4 2-acetylamino-4-chloro-6-(4-chlorobenzoyl)phenol 
• 85052-41-1 2-amino-4-chloro-6-(4-chlorobenzoyl)phenol 
• 122-01-0 4-chloro-benzoyl chloride 
• 105-36-2 ethyl bromoacetate 
• 676131-88-7 5-chloro-7-(4-chlorobenzoyl)-2-oxo-3H-benzoxazole 

Relevant articles and documents

Studies on novel 7-acyl-5-chloro-2-oxo-3H-benzoxazole derivatives as potential analgesic and anti-inflammatory agents

In this study, a series of (7-acyl-5-chloro-2-oxo-3H-benzoxazol-3-yl)alkanoic acid derivatives were synthesized and evaluated for their analgesic and anti-inflammatory activities by using the p-benzoquinone-induced writhing test and the carrageenan hind paw edema model, respectively. Acetic acid-induced peritoneal capillary permeability test and serotonin-induced hind paw edema test were also employed for the most active compounds. The test results indicated that (7-acyl-2-oxo-3H-benzoxazol-3-yl)alkanoic acids (Compounds 6 a-c, 8 a-c, 10 a-c) were equally or more potent analgesic and anti-inflammatory agents than aspirin and indomethacin respectively. The compounds 8 a and 8 c, but not 8 b which have the longest carbon chain on alkanoic acid moiety did not induce gastric lesion in mice.