67644-13-7Relevant academic research and scientific papers
Discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood
Liang, Jian-Hua,Yang, Liang,Wu, Si,Liu, Si-Si,Cushman, Mark,Tian, Jing,Li, Nuo-Min,Yang, Qing-Hu,Zhang, He-Ao,Qiu, Yun-Jie,Xiang, Lin,Ma, Cong-Xuan,Li, Xue-Meng,Qing, Hong
, p. 382 - 392 (2017/05/19)
Reduction of hippocampal neurogenesis caused by aging and neurological disorders would impair neural circuits and result in memory loss. A new lead compound (N-trans-3′,4'-methylenedioxystilben-4-yl acetamide 27) has been discovered to efficiently stimulate adult rats' neurogenesis. In-depth structure-activity relationship studies proved the necessity of a stilbene scaffold that is absent in highly cytotoxic analogs such as chalcones and heteroaryl rings and inactive analogs such as diphenyl acetylene and diphenyl ethane, and validated the importance of an NH in the carboxamide and a methylenedioxy substituent on the benzene ring. Immunohistochemical staining and biochemical analysis indicate, in contrast to previously reported neuroprotective chemicals, N-stilbenyl carboxamides have extra capacity for neuroproliferation-type neurogenesis, thereby providing a foundation for improving the plasticity of the adult mammalian brain.
Acetamidoarenediazonium Salts: Opportunities for Multiple Arene Functionalization
Schmidt, Bernd,Elizarov, Nelli,Riemer, Nastja,H?lter, Frank
, p. 5826 - 5841 (2015/09/15)
Unlike their ortho counterparts, meta- and para-acetamidoanilines can be converted into the corresponding acetamidoarenediazonium salts. These offer various opportunities for multiple Pd-catalyzed arene functionalization reactions, such as Matsuda-Heck-, Suzuki-Miyaura- or Fujiwara-Moritani couplings. Acetamidoarenediazonium salts, accessible from simple acetamidoanilines, are starting points for multiple Pd-catalyzed arene functionalization reactions.
PHOTOLYSIS OF para,α-SUBSTITUTED STILBENEDIAZONIUM SALTS WITH FORMATION OF LUMINESCENT PRODUCTS
Pavlova, N. V.,Eroshkin, V. I.
, p. 292 - 295 (2007/10/02)
Photochemical transformations of some para,α-substituted stilbenediazonium tetrafluoroborates were studied in terms of their possible use as the light-sensitive component of positive luminescent photographic materials.In acetonitrile solutions the photodecomposition of the title compounds proceeds by an ionic mechanism with formation of luminescent photoproducts.Quantum yield of photodecomposition of the salts on irradiation at λ corresponding to the longwave absorption band diminished upon introduction of para substituents such as OCH3 and N(CH3)2.
