7314-07-0Relevant articles and documents
Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands
Bian, Jiang,Liu, Yi-Qi,He, Jie,Lin, Xin,Qiu, Chen-Yang,Yu, Wen-Bo,Shen, Yan,Zhu, Ze-Yun,Ye, De-Yong,Wang, Jian,Chu, Yong
, (2021/10/06)
Parkinson's disease (PD) is the second most common neurodegenerative disorder. Early diagnosis is the key to treatment but is still a great challenge in the clinic now. The discovery of alpha-synuclein (α-syn) aggregates ligands has become an attractive s
Xanthate-mediated synthesis of (E)-alkenes by semi-hydrogenation of alkynes using water as the hydrogen donor
Luo, Xianglin,Chen, Xiuwen,Chen, Lu,Zhang, Kun,Li, Yibiao
supporting information, p. 2170 - 2173 (2019/02/24)
Semi-hydrogenation of alkynes is one of the most widely used methods for obtaining alkenes in laboratory preparation and in industry. Transition metal catalysts have been extensively studied for this transformation, but the tolerance of functional groups, such as pyridine,-OH,-NH2,-Bpin, and halides, and the toxicity of the trace amount of transition metal catalysts are still highly challenging. In this study, we report a general and robust strategy to achieve the semi-hydrogenation of alkynes using inexpensive and commercially available xanthate as the mediator. Mechanism studies support a non-radical process and H2O acts as the hydrogen donor.
Synthesis and anticancer activity of new azo compounds containing extended π-conjugated systems
Rezaei-Seresht, Esmail,Mireskandari, Erfan,Kheirabadi, Mitra,Cheshomi, Hamid,Rezaei-Seresht, Hasan,Aldaghi, Leila Sadat
, p. 1463 - 1469 (2017/07/25)
A series of novel azo compounds with extended π-conjugated systems were prepared by azo coupling reaction compounds trans-2-(4′-aminostyryl)-thiophene, 1-(4-aminophenyl)-4-phenyl-1,3-butadiene and 4-amino-4′-methoxystilbene with some phenols. The compounds were evaluated for their cytotoxicity against breast cancer adenocarcinoma (MCF-7), cervix adenocarcinoma (HeLa) and human embryonic kidney (HEK 293) cell lines using the MTT assay. The results showed all derivatives had more toxic effects than tamoxifen. Of all the compounds tested, the azo product obtained from coupling trans-2-(4′-Aminostyryl)-thiophene with 2-naphthol (compound 5b) exhibited the potent in vitro antiproliferative activity with IC50 27 ± 1 and 18 ± 0 μg/mL against MCF-7 and HeLa cell lines, respectively, while it was devoid of any cytotoxicity against normal HEK 293 cells even at 200 μg/mL.