65321-36-0

Basic information

• Product Name: tert-butyl pyridine-3-carboxylate
• Synonyms: 3-pyridinecarboxylic acid, 1,1-dimethylethyl ester; tert-Butyl nicotinate
• CAS NO: 65321-36-0
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.2157
• Mol File: 65321-36-0.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 239.5°C at 760 mmHg
• Flash Point: 98.7°C
• Density: 1.053g/cm³
• Vapor Pressure: 0.0399mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: tert-butyl pyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl pyridine-3-carboxylate(65321-36-0)
• EPA Substance Registry System: tert-butyl pyridine-3-carboxylate(65321-36-0)

Safety Data

• Hazardous Substances Data: 65321-36-0(Hazardous Substances Data)

Upstream product

• 59-67-6 nicotinic acid 
• 75-65-0 tert-butyl alcohol 
• 10400-19-8 3-pyridinecarbonyl chloride 
• 865-48-5 sodium t-butanolate 
• 100-55-0 3-hydroxymethylpyridin 
• 75-91-2 tert.-butylhydroperoxide 
• 865-47-4 potassium tert-butylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1692-25-7 3-pyridylboronic acid 
• 329214-79-1 3-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 
• 626-55-1 3-Bromopyridine 
• 201230-82-2 carbon monoxide 
• 93-60-7 methyl 3-pyridinecarboxylate 

Downstream Products

• 59-67-6 nicotinic acid 
• 115-11-7 isobutene 
• 676560-01-3 6-fluoronicotinic acid tert-butyl ester 
• 4695-77-6 1,4,5,6-tetrahydro-pyridine-3-carboxylic acid tert-butyl ester 

Relevant articles and documents

A larene/ fragrant mixedsurrounds uncle butanol method for preparing ester compounds

The invention discloses a preparation method of an aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound. The preparation method of the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound comprises the following steps of: firstly, under stirring condition, adding aromatic heterocycle borate compound or aromatic ring boric acid compound and di-tert-butyl dicarbonate ester into a solvent, and then adding a palladium catalyst and a ligand, so that a mixture A is obtained; secondly, heating the mixture A for carrying out reaction, and then cooling to room temperature, so that a mixture B is obtained; thirdly, diluting the mixture B with ethyl acetate, then filtering the diluted mixture B with diatomite, collecting filtrate, concentrating, and carrying out spin drying, so that the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound is obtained. The preparation method of the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound has the advantages that alkoxycarbonylation reaction on an aromatic heterocycle borate compound or aromatic ring boric acid compound is realized, and the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound is directly generated; raw materials are non-toxic, inexpensive and available; a catalytic system is low in cost and has good stability and broad applicability; reaction conditions are mild, safety is high, and control is easy; a technology is simple, operation is easy, environmental friendliness is realized, and specificity is strong, so that the preparation method of the aromatic ring/aromatic heterocycle tert-butyl alcohol ester compound is applicable to industrialized production.

A mesoporous organosilica grafted Pd catalyst (MOG-Pd) for efficient base free and phosphine free synthesis of tertiary butyl esters via tertiary-butoxycarbonylation of boronic acid derivatives without using carbon monoxide

A mesoporous organosilica grafted palladium(ii) catalyst was synthesized and characterized using various spectroscopic techniques. Its catalytic activity was evaluated for the synthesis of tertiary butyl esters via tert-butoxycarbonylation of boronic acid

An efficient method for the preparation of tertiary esters by palladium-catalyzed alkoxycarbonylation of aryl bromides

The palladium-catalyzed alkoxycarbonylation of aryl bromides is described for the efficient preparation of tertiary esters. The protocol proved compatible with a wide variety of functionalized (hetero)aromatic bromides, as well as several different sterically hindered tertiary alcohols, affording the alkoxycarbonylated products in high yields. Finally, the formation of aromatic trityl esters is discussed.