67693-58-7

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 67693-57-6 4-(p-fluorophenoxy)-3-hydroxy-1-butyne 
• 288-32-4 1H-imidazole 
• 59769-38-9 2-(4-fluorophenoxy)acetaldehyde 

Downstream Products

• 88462-73-1 trans-4-(p-Fluorophenoxy)-3-hydroxy-1-iodobut-1-ene 
• 67693-59-8 trans-4-(p-Fluorophenoxy)-1-tributylstannyl-3-trimethylsiloxybut-1-ene 

Relevant academic research and scientific papers

PROSTANOIDS. V. THE ω-CHAIN FOR 16-ARYLOXYTETRANORPROSTAGLANDINS

During hydrostannylation of 4-aryloxy-3-hydroxy-1-butynes and subsequent cleavage of the obtained E-vinylstannates with iodine the corresponding E-1-iodo-3-hydroxy-4-aryloxy-1-butenes were synthesized.

1-Hydroxymethyl-1-1-oxo prostane derivatives of the E and F series

The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: STR1 wherein R is an alkyl group and R15 is C1 -C4 alkyl, C1 -C4 alkoxy, di-C1 -C4 -alkylamino, and phenyl orphenyl substituted with one or more substituents selected from the group consisting of C1 -C4 alkyl, OR, SR, F, or Cl wherein R is as previously defined.

1-Substituted-1-oxo-prostane-derivatives of the E, A and F series

The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E, F, or A series having on the terminal methylene carbon of the alpha chain, a substituent selected from the group consisting of: STR1 wherein R is C1 to C6 alkyl, and phenyl or phenyl substituted with one or more substituents selected from the group consisting of C1 -C4 alkyl, OR16, SR16, F, or Cl, and R16 is C1 to C6 alkyl.

11-(2-Hydroxyethylthio) prostenoic acid E and F series derivatives

This disclosure describes certain 11-(2-hydroxyethylthio) prostenoic acid E and F series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.

1-Hydroxymethyl-1-oxo-prostane derivatives of the E2 series

Derivatives, analogs, and congeners of prostane having a 1-(hydroxymethyl)-1-oxo-prostane structure in the E2 series.

11-(2-Hydroxyethylthio)prostenoic acid E2 series derivatives

This disclosure describes certain 11-(2-hydroxyethylthio)-9-keto-prostenoic acid E series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.