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Usage

Uses

Used in Pharmaceutical Industry:
Diformyl dapsone is used as an antibacterial agent for the treatment of dermatitis herpetiformis, a chronic skin condition characterized by a group of blisters and severe itching. Its effectiveness in treating this condition is attributed to its ability to inhibit the growth of bacteria responsible for the infection.
Used in Respiratory Medicine:
Diformyl dapsone is used as an effective treatment for murine and human P. carinii pneumonitis, a lung infection caused by the Pneumocystis carinii fungus. Its potent antibacterial properties make it a valuable asset in the management and treatment of this respiratory condition.

Upstream product

• 64-18-6 formic acid 
• 80-08-0 dapsone 
• 80-07-9 4,4'-dichlorodiphenyl sulphone 

Downstream Products

• 3117-85-9 C₁₄H₈N₂O₂S 
• 1620164-65-9 octaethyl sulfonyldiphenyl-4,4`-bis[aminomethylidene(bisphosphonate)] 
• 1620164-72-8 sulfonyldiphenyl-4,4`-bis[aminomethylidene(bisphosphonic)] acid 

Relevant academic research and scientific papers

Acidic ionic liquid immobilized on nanoporous Na+-montmorillonite as an efficient and reusable catalyst for the formylation of amines and alcohols

In this work, nanoporous sodium montmorillonite clay (Na+-MMT) was used as a support for the immobilization of 1-methyl-3-(trimethoxysilylpropyl)-imidazolium hydrogen sulfate. The Na+-MMT chemical modification ([Na+-MMT-[pmim]HSO4) was confirmed by a variety of techniques including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy and potentiometric titration. The catalytic performance of this immobilized acidic ionic liquid was probed for the N-formylation of a variety of amines using formic acid under solvent-free conditions. This reagent is also useful for the formylation of benzylic alcohols. The procedure gave the products in excellent yields in very short reaction times. Also, this catalyst can be reused ten times without loss of its catalytic activity.

Synthesis and antiproliferative activity of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids

A series of aromatic and aliphatic bis[aminomethylidene(bisphosphonic)] acids was synthesized in the reaction of triethylphosphite with isonitriles followed by hydrolysis or dealkylation. The in vitro anti-proliferative effect of all synthesized tetraphosphonic acids against MCF-7 breast cancer cells, J774E macrophages and HL-60 promyelocytic leukemia cells was determined. Three aromatic derivatives (5a, 5f and 5j) showed a similar or higher anti-proliferative activity than zoledronic acid.