6784-61-8

Usage

Uses

Used in Pharmaceutical Industry:
1-Piperidinoacetone is used as an intermediate in the synthesis of drugs for its ability to undergo a variety of chemical reactions, contributing to the production of various pharmaceuticals and organic compounds.
Used in Synthesis of Antihistamines:
1-Piperidinoacetone is used as a key component in the creation of antihistamines, serving as a precursor that aids in the development of medications designed to counteract allergic reactions.
Used in Synthesis of Antipsychotics:
1-Piperidinoacetone is utilized as a starting material in the production of antipsychotic medications, playing a crucial role in the synthesis process to create drugs that treat psychiatric disorders.
Used in Organic Compounds Synthesis:
1-Piperidinoacetone is employed as a versatile intermediate for the synthesis of a wide range of organic compounds, leveraging its reactivity to form different products in chemical processes.

InChI:InChI=1/C8H15NO/c1-8(10)7-9-5-3-2-4-6-9/h2-7H2,1H3

Upstream product

• 110-89-4 piperidine 
• 78-95-5 chloroacetone 
• 2684-62-0 diazoacetone 
• 3010-03-5 piperidin-1-yl-acetonitrile 
• 75-16-1 methylmagnesium bromide 
• 56-81-5 glycerol 
• 2156-71-0 N-chloropiperidine 
• 67-64-1 acetone 

Downstream Products

• 467-83-4 dipipanone 
• 24153-57-9 4,4-diphenyl-6-piperidino-heptan-3-one-imine 
• 17371-45-8 3-methyl-2,2-diphenyl-4-piperidino-butyronitrile 
• 5424-11-3 2,2-diphenyl-4-piperidino-valeronitrile 
• 110246-10-1 1-(1-methyl-3,3-diphenyl-propyl)-piperidine 
• 110244-53-6 1-(2-methyl-3,3-diphenyl-propyl)-piperidine 
• 698-92-0 1-(2-chloro-propyl)-piperidine 
• 110-89-4 piperidine 
• 67-63-0 isopropyl alcohol 
• 63442-69-3 1-Piperidino-2-propanon-oxim 
• 934-90-7 1-(piperidin-1-yl)propan-2-ol 
• 101455-07-6 (E)-4-(4-Methoxy-phenyl)-1-piperidin-1-yl-but-3-en-2-ol 

Relevant academic research and scientific papers

Theoretical and model studies on the chemoselectivity of a Grignard reagent's reaction with a combined aminonitrile-oxazolidine system

Semi-empirical quantum chemical studies using PM3 suggest that the preferred reaction between a Grignard reagent and a combined aminonitrile-oxazolidine system involves initial formation of a Lewis acid-base complex between magnesium and the central nitrogen atom, followed by preferred reaction with the aminonitrile function; model studies confirm that this reaction proceeds by addition rather than substitution.

Preparation method of N-acetonyl amine compound

The invention discloses a preparation method of an N-acetonyl amine compound. The method comprises the following steps that an amine compound and glycerin are used as reaction raw materials, and in the presence of a composite catalyst and an alkali addition agent, in reaction mediums and at the reaction temperature of 80-180 DEG C, a reaction is performed for 2-48 hours in a sealed reactor so that the N-acetonyl amine compound is obtained. The method disclosed by the invention is simple, reaction conditions are mild, target products can be obtained at a low cost and at a high yield, and the used catalyst has high catalytic activity and is easy to separate and repeatedly use in a reaction system; besides, the whole process is environment-friendly, and the utilization of by-products namely the glycerin of biologic diesel oil is promoted.

Glycerol as a Building Block for Prochiral Aminoketone, N-Formamide, and N-Methyl Amine Synthesis

Prochiral aminoketones are key intermediates for the synthesis of optically active amino alcohols, and glycerol is one of the main biomass-based alcohols available in industry. In this work, glycerol was catalytically activated and purposefully converted with amines to generate highly valuable prochiral aminoketones, as well as N-formamides and N-methyl amines, over CuNiAlOx catalyst. The catalyst structure can be anticipated as nano-Ni species on or in CuAlOx via the formation of nano- Cu?Ni alloy particles. This concept may present a novel and valuable methodology for glycerol utilization.

The Rabe amination after a century: Direct addition of N-heterocycles to carbonyl compounds

A catalytic version of the Rabe electrophilic amination is presented. This kind of reaction was originally employed in 1918 in a key step for the conversion of quinotoxine to quinine. Ketones and α-substituted aldehydes give the corresponding α-aminated carbonyl compounds in moderate yield. α,α-Unsubstituted aldehydes give rise to amino ketones via a novel rearrangement.

Highly chemoselective α-diazo carbonyl insertion reactions into N-H and S-H bonds catalysed by [RuCl(η5-C5H5)(PPh3)2]

Complex [RuCl(η5-C5H5)(PPh3)2], in chloroform at 60 deg C, catalyses the chemoselective insertion of α-diazo carbonyl compounds into N-H and S-H bonds to afford α-keto-amines and α-keto-thioethers.

Method of manufacturing ketones

The invention relates to a method for the manufacture of ketones which comprises oxidizing an n-olefin in the presence of a catalyst containing palladium, copper, a halogen, and at least one of specific tertiary amines.