67895-75-4

Upstream product

• 71841-56-0 ethyl 3-(2-methoxy-4-methylphenyl)butanoate 
• 323195-82-0 Ethyl (2E)-3-(2-methoxy-4-methylphenyl)but-2-enoate 
• 6921-64-8 4'-hydroxy-2'-methylacetophenone 
• 55919-62-5 2-(2-methoxy-4-methylphenyl)propan-1-ol 
• 342618-22-8 1-bromo-2-(2-methoxy-4-methylphenyl)propane 
• 39701-08-1 2-methoxy-4-methyl-1-(prop-1-en-2-yl)benzene 
• 35633-35-3 2-methoxy-4-methylacetophenone 
• 762296-24-2 2-methyl-6-(2-methoxy-4-methylphenyl)hept-2-ene-3-ol 
• 67-64-1 acetone 
• 175735-91-8 [4-(2-Methoxy-4-methyl-phenyl)-2-oxo-pentyl]-phosphonic acid dimethyl ester 

Relevant academic research and scientific papers

Facile synthesis of (±)-parahigginone methyl ether and (±)-curcuphenol

Using Grinard coupling as a key step, a facile synthetic approach to (±)-parahigginone methyl ether 1 and (±)-curcuphenol 2 has been achieved by five steps with 42.3% and 58.6% overall yield, respectively.

Synthesis of (±)-2-methyl-(2'-hydroxy-4'-methylphenyl)-2-hepten-4-one (Turmeronol B)

The first total synthesis of the racemic compound is described. 2-Hydroxy-4-methylacetophenone was used as starting material and transformed into the target molecule in 6 steps. The synthetic Turmeronol B displays spectral properties identical to those reported for the natural compound leading to the confirmation of the proposed structure.