6797-50-8Relevant academic research and scientific papers
Hemoglobin: A New Biocatalyst for the Synthesis of 2-substituted Benzoxazoles via Oxidative Cyclization
Li, Fengxi,Li, Zhengqiang,Tang, Xuyong,Cao, Xinyu,Wang, Chunyu,Li, Jialin,Wang, Lei
, p. 1192 - 1195 (2019/02/07)
Efficient and mild synthesis of a series of 2-substituted benzoxazoles via oxidative cyclization catalyzed by hemoglobins reported here for the first time. Satisfactory yields (84 %–97 %) and mild reaction conditions make this method highly viable for practical applications.
A by bio-catalytic oxidation cyclized synthesis of 2 - substituted benzoxazole compound green method (by machine translation)
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Paragraph 0050; 0051; 0052, (2018/10/11)
The invention discloses a by bio-catalytic oxidation cyclized synthesis of 2 - substituted benzoxazole compound green method, which belongs to the technical field of biological catalytic synthesis, uses aldehyde and phenol amine or benzoxazole and cyclic secondary amine as the substrate of reaction, methylene chloride as the solvent, biological protein as a catalyst. Operation comprises the following steps first reaction to produce intermediate of the reaction substrate, then the hemoglobin, the oxidizing agent, the solvent is added in a reaction vessel, the reaction at room temperature under the condition of 2 hours. The experiment shows that, various types of hemoglobin and horse radish peroxidase and heme to said reaction have a catalytic effect, wherein the Vitreoscilla hemoglobin catalytic effect is the best, yield is up to 91%, superior to the traditional chemical synthesis method. The use of hemoglobin catalysts such as than the traditional chemical synthesis method more green environmental protection, is characterized in that: there are no harmful reagent to use, may be any metal ion catalysis, reduce the amount of the oxidizing agent and the catalyst. (by machine translation)
Copper-catalyzed alkylation of benzoxazoles with secondary alkyl halides
Ren, Peng,Salihu, Isuf,Scopelliti, Rosario,Hu, Xile
supporting information; experimental part, p. 1748 - 1751 (2012/05/20)
Copper-catalyzed direct alkylation of benzoxazoles using nonactivated secondary alkyl halides has been developed. The best catalyst is a new copper(I) complex (1), and the reactions are promoted by bis[2-(N,N-dimethylamino)ethyl] ether.
