6797-70-2

Usage

Uses

Used in Pharmaceutical Industry:
α-(DiethylaMino)benzeneacetic Acid Ethyl Ester is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its ability to form α-aminoaldehydes makes it a valuable reagent in the preparation of complex organic molecules, which can be further utilized in the development of new drugs and therapeutic agents.
Used in Chemical Research:
In the field of chemical research, α-(DiethylaMino)benzeneacetic Acid Ethyl Ester serves as a versatile reagent for the synthesis of various organic compounds. Its unique chemical properties enable researchers to explore new reaction pathways and develop innovative synthetic methods, contributing to the advancement of chemical science.
Used in Organic Synthesis:
α-(DiethylaMino)benzeneacetic Acid Ethyl Ester is used as a key building block in organic synthesis, particularly for the preparation of α-aminoaldehydes. These α-aminoaldehydes can be further transformed into a wide range of organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals, making it an essential component in the synthesis of various industrial products.

Upstream product

• 22065-57-2 ethyl 2-phenyldiazoacetate 
• 109-89-7 diethylamine 
• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 925-90-6 ethylmagnesium bromide 
• 60734-12-5 3-hydroxy-2-phenylacrylic acid ethyl ester 
• 927-77-5 n-propylmagnesium bromide 
• 1418119-50-2 (E)-ethyl 2-(4-toluenesulfonyloxyimino)-2-phenylacetate 
• 135765-81-0 (E)-ethyl 2-hydroxyimino-2-phenylacetate 
• 1086217-03-9 (Z)-ethyl 2-(4-toluenesulfonyloxyimino)-2-phenylacetate 
• 1418119-49-9 (E)-ethyl 2-(2,4-dichlorobenzenesulfonyloxyimino)-2-phenylacetate 
• 1418119-52-4 (E)-ethyl 2-(4-nitrobenzenesulfonyloxyimino)-2-phenylacetate 
• 122806-03-5 Benzotriazol-1-yl-diethylamino-acetic acid ethyl ester 

Relevant academic research and scientific papers

Umpolung Reactions of α-Tosyloximino Esters in a Flow System

An umpolung reaction of α-tosyloximino esters in a flow system is disclosed. Tandem N, N-dialkylations with two different Grignard reagents gave the desired N, N-dialkylated products in moderate to good yields. In addition, a tandem N, N, C-trialkylation of an α-tosyloximino ester with three different Grignard reagents has been successfully achieved to afford the desired N, N, C-trialkylated product in moderate yield.

Highly efficient sequential N,N,C-trialkylation of α-N-acyloxyimino esters

α-N-Acyloxyimino esters serve as highly efficient substrates for the N,N,C-trialkylation reaction that can introduce various patterns of nucleophiles at the imino nitrogen and carbon atoms to synthesize N,N-dialkylated and N,N,C-trialkylated α-amino esters in moderate to high yields.

N,N-Di- and N,N,C-Trialkylation of δ-sulfoximino esters

N,N-Dialkylation of α-sulfoximino esters with Grignard reagents proceeds to give α-N,N-dialkylamino esters. N,N,CTrialkylated product is also obtained via the oxidation and nucleophilic addition reaction of the intermediary enolate.

Catalytic insertion of diazo compounds into N-H bonds: The copper alternative

The complexes TpXCu (TpX = homoscorpionate) catalyse the insertion of diazo compounds into nitrogen-hydrogen bonds of amines and amides, under very mild conditions, with quantitative yields being obtained with equimolar ratios of reactants.

The Chemistry of N-Substituted Benzotriazoles Part 23. Synthesis of Tertiary α-Amino Esters

2-Dialkylaminoalkanoic esters 6 are prepared in good yield by the reaction of organozinc derivatives 5 with dialkylamino(1-benzotriazolyl)acetic esters 4, obtained from the condensation of secondary amines 3 with ethyl glyoxylate 2 and benzotriazole 1.