67996-22-9Relevant academic research and scientific papers
N-Heterocyclic Carbene-Catalyzed β-Indolylation of α-Bromoenals with Indoles
Sun, Shaofa,Lang, Ming,Wang, Jian
supporting information, p. 5704 - 5708 (2019/12/24)
An unprecedented example of NHC-catalyzed β-indolylation of α-bromoenals with indoles has been developed. This concise protocol features several advantages (mild reaction conditions, broad substrate scope) and constructs synthetically useful building blocks, namely β-biaryl methylene esters. Notably, the β-biaryl methylene-type fragment is widely found in natural products or pharmaceuticals. (Figure presented.).
Asymmetric Friedel-Crafts reactions: Catalytic enantioselective addition of aromatic and heteroaromatic C-H bonds to activated alkenes, carbonyl compounds, and imines
J?rgensen, Karl Anker
, p. 1117 - 1125 (2007/10/03)
The development and scope of catalytic enantioselective addition of aromatic and heteroaromatic C-H bonds to α,β-unsaturated alkenes, carbonyl compounds, and imines are presented, α,β-Unsaturated alkenes, 4-substituted 2-oxo-3-butenoate esters and alkylid
Catalytic enantioselective alkylation of heteroaromatic compounds using alkylidene malonates
Zhuang,Hansen,Jorgensen
, p. 347 - 348 (2007/10/03)
A catalytic enantioselective alkylation of heteroaromatic compounds using alkylidene malonates has been developed; the reaction proceeds for different heteroaromatic compounds with alkylidene malonates in high yield and enantiomeric excess.
Meldrum's Acid in Organic Synthesis. V. Versatile One-pot Synthesis of Indolepropionic Esters via Simultaneous Condensation of Three Different Carbon Components, Indole, Aldehydes and Meldrum's Acid
Oikawa, Yuji,Hirasawa, Hitoshi,Yonemitsu, Osamu
, p. 3092 - 3096 (2007/10/02)
When an acetonitrile solution of Meldrum's acid (1), indole (5), and an aliphatic or aromatic aldehyde (8) in the presence of a small amount of proline (except in the case of acetaldehyde) was allowed to stand at 30 deg C, a simultaneous condensation of t
