6803-02-7

Basic information

• Product Name: 8-Hydroxy-6-methoxy-3-methylisochroman-1-one
• Synonyms: 8-Hydroxy-6-methoxy-3-methylisochroman-1-one;6-methoxy-8-hydroxy-3-methyl-3,4-dihydroisocoumarin;3,4-Dihydro-8-hydroxy-6-methoxy-3-methyl-1H-2-benzopyran-1-one;3-Methyl-6-methoxy-8-hydroxy-3,4-dihydroisocoumarin;3-Methyl-6-methoxy-8-hydroxyisochroman-1-one;Methoxymellein;1H-2-Benzopyran-1-one, 3,4-dihydro-8-hydroxy-6-methoxy-3-methyl-;2,4-Dihydro-8-hydroxy-6-methoxy-3-methyl-1H-2-benzopyran-1-one
• CAS NO: 6803-02-7
• Molecular Formula: C11H12O4
• Molecular Weight: 0
• Mol File: 6803-02-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 444.2°C at 760 mmHg
• Flash Point: 180.2°C
• Appearance: /
• Density: 1.252g/cm³
• Vapor Pressure: 1.66E-08mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 8-Hydroxy-6-methoxy-3-methylisochroman-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Hydroxy-6-methoxy-3-methylisochroman-1-one(6803-02-7)
• EPA Substance Registry System: 8-Hydroxy-6-methoxy-3-methylisochroman-1-one(6803-02-7)

Safety Data

• Hazardous Substances Data: 6803-02-7(Hazardous Substances Data)

Usage

Definition

ChEBI: An isochromane that is mellein bearing a methoxy substituent at position 6.

InChI:InChI=1/C11H12O4/c1-6-3-7-4-8(14-2)5-9(12)10(7)11(13)15-6/h4-6,12H,3H2,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 19314-92-2 3,4-dihydro-6,8-dihydroxy-3-methylisochromen-1-one 
• 1702-86-9 8-hydroxy-6-methoxy-3-methylisocoumarin 
• 77844-97-4 3,4-dihydro-6,8-dimethoxy-3-methyl-1H-2-benzopyran-1-one 
• 143112-16-7 3-Ethyl-5,7-dimethoxy-3H-isobenzofuran-1-one 
• 91-52-1 2,4 dimethoxybenzoic acid 
• 930285-77-1 2-allyl-4,6-dimethoxybenzoic acid 
• 3465-69-8 5,7-dimethoxyphthalide 
• 82218-07-3 4-carboxy-6,8-dimethoxy-3-methylisocoumarin 
• 83375-20-6 2,4-dimethoxy-6-(methoxycarbonylmethyl)benzoic acid 
• 3686-57-5 2,4-dimethoxy-6-methylbenzoic acid 
• 18110-66-2 6,8‐dimethoxy‐3‐methylisocoumarin 
• 82218-06-2 6,8-dimethoxy-1H-2-benzopyran-1,3(4H)-dione 
• 4778-99-8 2-carboxymethyl-4,6-dimethoxy-benzoic acid 

Relevant articles and documents

Catalytic C-N and C-H Bond Activation: Ortho-Allylation of Benzoic Acids with Allyl Amines

A facile insertion of ruthenium into aromatic C-H and allylic C-N bonds are the key steps in a [Ru(p-cymene)Cl2]2-catalyzed ortho-C-H allylation of benzoic acids. This protocol allows drawing on the large pool of allylic amines for state-of-the-art ortho-functionalizations of arenes, turning neutral amines into leaving groups. Concise syntheses of biologically active compounds provide further evidence of the synthetic potential of this methodology.

Novel AlCl3 catalysed syntheses of naturally occurring (±) 8-Hydroxy-3-methyl-3,4-dihydroisocoumarins

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Synthesis of Chlorinated Isocoumarin Derivatives

Syhtheses of 5-chloro-, 7-chloro-, and 5,7-dichloro-isocoumarin derivatives, including the fungal metabolites 5-chloro-3,4-dihydro-8-hydroxy-6-methoxy-3-methylisocoumarin (3), 7-chloro-3,4-dihydro-8-hydroxy-6-methoxy-3-methylisocoumarin (2), and 5,7-dichl