6803-02-7

Usage

Definition

ChEBI: An isochromane that is mellein bearing a methoxy substituent at position 6.

InChI:InChI=1/C11H12O4/c1-6-3-7-4-8(14-2)5-9(12)10(7)11(13)15-6/h4-6,12H,3H2,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 19314-92-2 3,4-dihydro-6,8-dihydroxy-3-methylisochromen-1-one 
• 1702-86-9 8-hydroxy-6-methoxy-3-methylisocoumarin 
• 77844-97-4 3,4-dihydro-6,8-dimethoxy-3-methyl-1H-2-benzopyran-1-one 
• 82218-06-2 6,8-dimethoxy-1H-2-benzopyran-1,3(4H)-dione 
• 83375-20-6 2,4-dimethoxy-6-(methoxycarbonylmethyl)benzoic acid 
• 91-52-1 2,4 dimethoxybenzoic acid 
• 930285-77-1 2-allyl-4,6-dimethoxybenzoic acid 
• 3465-69-8 5,7-dimethoxyphthalide 
• 82218-07-3 4-carboxy-6,8-dimethoxy-3-methylisocoumarin 
• 3686-57-5 2,4-dimethoxy-6-methylbenzoic acid 
• 4778-99-8 2-carboxymethyl-4,6-dimethoxy-benzoic acid 
• 18110-66-2 6,8‐dimethoxy‐3‐methylisocoumarin 
• 143112-16-7 3-Ethyl-5,7-dimethoxy-3H-isobenzofuran-1-one 

Relevant academic research and scientific papers

Catalytic C-N and C-H Bond Activation: Ortho-Allylation of Benzoic Acids with Allyl Amines

A facile insertion of ruthenium into aromatic C-H and allylic C-N bonds are the key steps in a [Ru(p-cymene)Cl2]2-catalyzed ortho-C-H allylation of benzoic acids. This protocol allows drawing on the large pool of allylic amines for state-of-the-art ortho-functionalizations of arenes, turning neutral amines into leaving groups. Concise syntheses of biologically active compounds provide further evidence of the synthetic potential of this methodology.

COMPOUNDS AND COMPOSITIONS USEFUL IN THE TREATMENT OF NEOPLASIA

There is described compounds for use in therapy, said compounds being defined by Formula (1): There is also described an anti-proliferative composition comprising one or more compounds according to Formula (1), and a method of treatment of neoplasia comprising the administration of such a compound or composition.

THE CHEMISTRY OF THE BLUE STAIN FUNGI. PART 3. SOME METABOLITES OF CERATOCYSTIS MINOR (HEDGCOCK) HUNT

The metabolites formed in still cultures by Ceratocystis minor, one of the fungal species associated with the blue stain disease of pine, have been isolated and identified as ceratenolone (5), 6,8-dihydroxy-3-methylisocoumarin (2), 8-hyroxy-6-methoxy-3-methylisocoumarin (8), 3,4-dihydro-6,8-dihydroxy-3-methylisocoumarin (10), 3,4-dihydro-3-methyl-3,6,8-trihydroxy-3-methylisocoumarin (12), 3,4-dihydro-3-methyl-3,4,6,8-tetrahydroxyisocoumarin (13), and succinic acid.Ceratenolone (5), a new type natural product, forms an intensely blue chelate with ferric ions.This chelate may be responsible for the blue coloration of the pine infected by Ceratocystis minor.

Synthesis of Chlorinated Isocoumarin Derivatives

Syhtheses of 5-chloro-, 7-chloro-, and 5,7-dichloro-isocoumarin derivatives, including the fungal metabolites 5-chloro-3,4-dihydro-8-hydroxy-6-methoxy-3-methylisocoumarin (3), 7-chloro-3,4-dihydro-8-hydroxy-6-methoxy-3-methylisocoumarin (2), and 5,7-dichl