680612-97-9Relevant academic research and scientific papers
Synthesis of 3-aryl/heteroaryl-1-methyl-1H-indazoles and evaluation of their biological activities
Mohan, Arasavelli Ananda,Sharma, Ganapavarapu V. R.,Vidavalur, Siddaiah
, p. 287 - 294 (2018/09/14)
The synthesis of 3-aryl/heteroaryl-1-methyl-1H-indazole derivatives (5a-j) was achieved from commercially available 1H-indazole through the Suzuki cross-coupling reaction. The indazoles 5a-j were synthesized through two alternative routes (Route 1 and Route 2) from the same starting material and characterized using1H nuclear magnetic resonance (NMR),13C NMR, infrared, and liquid chromatography-mass spectrometry data. The first step which is common step to both routes involves conversion of 1H-3-iodo-1H-indazole (2). The antibacterial activity of 5a-j and intermediates 3a-j was evaluated against two Gram-positive and two Gram-negative bacterial strains and anticancer activity against HT-29 and MDA-MB-231cancer cell lines.
Synthesis of 3-aryl-1H-indazoles via iridium-catalysed C-H borylation and Suzuki-Miyaura coupling
Egan, Ben A.,Burton, Paul M.
, p. 27726 - 27729 (2014/07/21)
The regioselective iridium-catalysed C3-borylation of 1H-indazoles has been achieved. Subsequent Suzuki-Miyaura coupling of the boronate esters with aryl chlorides, bromides and iodides affords 3-aryl-1H-indazoles in good yields. This journal is the Partn
