52088-10-5

Basic information

• Product Name: 3-IODO-1-METHYL-1H-INDAZOLE
• Synonyms: 3-IODO-1-METHYL-1H-INDAZOLE;3-iodo-1-methyl-1H-indazole(SALTDATA: FREE)
• CAS NO: 52088-10-5
• Molecular Formula: C₈H₇IN₂
• Molecular Weight: 258.06
• Mol File: 52088-10-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 318.4°C at 760 mmHg
• Flash Point: 146.4°C
• Appearance: /
• Density: 1.89g/cm³
• Vapor Pressure: 0.000673mmHg at 25°C
• Refractive Index: 1.718
• Storage Temp.: 2-8°C(protect from light)
• PKA: -0.09±0.50(Predicted)
• CAS DataBase Reference: 3-IODO-1-METHYL-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-IODO-1-METHYL-1H-INDAZOLE(52088-10-5)
• EPA Substance Registry System: 3-IODO-1-METHYL-1H-INDAZOLE(52088-10-5)

Safety Data

• Hazardous Substances Data: 52088-10-5(Hazardous Substances Data)

Usage

General Description

3-Iodo-1-methyl-1H-indazole is a chemical compound with the formula C8H7IN. It is a derivative of indazole, a bicyclic aromatic heterocycle. The presence of an iodo group in the molecule makes it potentially useful in various chemical and pharmaceutical applications. The compound's structural and electronic properties may also make it a valuable building block in the synthesis of more complex organic molecules. Due to its unique chemical structure, 3-Iodo-1-methyl-1H-indazole may possess interesting pharmacological and biological properties, making it a subject of interest for researchers in the pharmaceutical and biotech industries.

InChI:InChI=1/C8H7IN2/c1-11-7-5-3-2-4-6(7)8(9)10-11/h2-5H,1H3

Upstream product

• 66607-27-0 3-iodoindazole 
• 74-88-4 methyl iodide 
• 52354-77-5 3-iodo-1,2-dimethyl-indazolium; iodide 
• 271-44-3 benzimidazole 
• 124-41-4 sodium methylate 

Downstream Products

• 13436-48-1 1-methyl-1H-indazole 
• 680612-97-9 4-(1-methyl-1H-indazol-3-yl)phenol 
• 51093-44-8 3‐(4‐methoxyphenyl)‐1‐methyl‐1H‐indazole 
• 329220-10-2 3-(4-fluorophenyl)-1-methyl-1H-indazole 
• 51093-42-6 1‐methyl‐3‐phenyl‐1H‐indazole 
• 1627722-97-7 1-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole 

Relevant articles and documents

Synthesis of 3-aryl/heteroaryl-1-methyl-1H-indazoles and evaluation of their biological activities

The synthesis of 3-aryl/heteroaryl-1-methyl-1H-indazole derivatives (5a-j) was achieved from commercially available 1H-indazole through the Suzuki cross-coupling reaction. The indazoles 5a-j were synthesized through two alternative routes (Route 1 and Route 2) from the same starting material and characterized using1H nuclear magnetic resonance (NMR),13C NMR, infrared, and liquid chromatography-mass spectrometry data. The first step which is common step to both routes involves conversion of 1H-3-iodo-1H-indazole (2). The antibacterial activity of 5a-j and intermediates 3a-j was evaluated against two Gram-positive and two Gram-negative bacterial strains and anticancer activity against HT-29 and MDA-MB-231cancer cell lines.

Palladium complexes with 1-methyl-3-phenylindazole ligands

1-Methyl-3-phenylindazole reacts with lithium tetrachloropalladate and palladium acetate to give new coordination and (C,N)-cyclometallated dimeric and monomeric palladium complexes.

HISTONE DEMETHYLASE INHIBITORS

The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted 3-aminopyridine derivative compounds, substituted 3-aminopyridazine derivative compounds, and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.