68196-10-1

Upstream product

• 5447-87-0 2-(1-phenylethylidene)propanedinitrile 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 

Downstream Products

• 131003-90-2 2-[((1S,2R,3R,3aR)-1-Benzoyl-2-phenyl-1,2,3,3a-tetrahydro-pyrrolo[1,2-a]quinolin-3-yl)-phenyl-methylene]-malononitrile 
• 131003-91-3 2-[((1S,2S,3R,10bR)-3-Benzoyl-2-phenyl-1,2,3,10b-tetrahydro-pyrrolo[2,1-a]isoquinolin-1-yl)-phenyl-methylene]-malononitrile 
• 142071-72-5 2-[((1R,2R,3S,8aR)-3-Benzoyl-6-cyano-2-phenyl-1,2,3,8a-tetrahydro-indolizin-1-yl)-phenyl-methylene]-malononitrile 
• 131003-85-5 (1R,2R,3S,8aR)-3-Benzoyl-1-(2,2-dicyano-1-phenyl-vinyl)-2-phenyl-1,2,3,8a-tetrahydro-indolizine-6-carboxylic acid ethyl ester 
• 60847-65-6 4,6-diphenyl-2-ethoxypyridine-3-carbonitrile 
• 912900-75-5 3-benzoyl-1-(2,2-dicyano-1-phenylvinyl)-2-phenyl-2,3-dihydroindolizine 

Relevant academic research and scientific papers

Nitrile-assisted oxidation over oxidative-annulation: Pd-catalyzed α,β-dehydrogenation of α-cinnamyl β-keto nitriles

A palladium-catalyzed oxidation reaction is disclosed where the nitrile functionality on the substrate simply changes the course of the reaction. Our previous finding showed that using the Pd(ii)-catalyst in the presence of benzoquinone as an oxidant, 2-cinnamyl-1,3-dicarbonyls provides functionalized furans via oxidative cyclization. When a nitrile group is replaced with one of the carbonyl functionalities of the same substrate, the oxidative cyclization was completely suppressed; instead, the oxidation at the α,β-position occurred to provide α,β,γ,δ-diene containing β-keto nitriles.

Phosphine-catalyzed domino reaction: A novel sequential [2+3] and [3+2] annulation reaction of γ-substituent allenoates to construct bicyclic[3, 3, 0]octene derivatives

We have successfully developed a novel and efficient phosphine-catalyzed sequential [2+3] and [3+2] annulation reaction of γ-substituent allenoates to construct bicyclic[3, 3, 0]octene derivatives. The protocol uses readily available γ-substituent allenoa

Studies of Polyfunctionally Substituted Heteroaromatics: Synthesis of New Polyfunctionally Substituted Azabiaryls

The styryl derivatives 1a-e reacted with malononitrile by refluxing in ethanolic sodium ethoxide solution to yield the polyfunctionally substituted pyridine derivatives 4a-e rather than 7a-e, respectively.Compounds 4a-k were also obtained via condensation

STEREOSELECTIVE s + ?2s>-DIPOLAR CYCLOADDITION OF PYRIDINIUM YLIDES TO NITRILES OF THE trans-1,3-BUTADIENE SERIES. CRYSTAL AND MOLECULAR STRUCTURE OF 3-BENZOYL-1-(2,2-DICYANO-1-CYCLOPROPYLVINYL)-2-PHENYL-6-CYANO-1,2-trans-2,3-trans-1,9-trans-1,2,3,9-TETRAHYDROINDOLIZINE

The interaction of substituted trans-1,1-dicyano-4-phenyl-1,3-butadienes with pyridinium ylides proceeds through the path of s + ?2s>-dipolar cycloaddition, highly regioselective and stereoselective, with formation of substituted 1-(2,2-dicyanovinyl)-2-phenyl-6-cyano-1,2-trans-2,3-trans-1,9-trans-1,2,3,9-tetrahydroindolizines.The stereoselectivity of these reactions is due to endo-addition of molecules of trans-1,3-butadienes to the anti form of pyridinium ylides; it is confirmed by correlation analysis of the data from double PMR, mathematical calculations of torsion angles, and X-ray structural studies of the substituted tetrahydroindolizines.