487-27-4 Usage
Uses
Used in Pharmaceutical Industry:
Scopoline is used as an antiemetic and anti-motion sickness agent for its ability to alleviate nausea, vomiting, and motion sickness. It is particularly effective in treating these symptoms due to its potent anticholinergic effects.
Used in Surgical Procedures:
Scopoline is used as a sedative and anesthetic adjunct in patients undergoing surgery or medical procedures. Its calming and relaxing effects help to reduce anxiety and ensure a smoother surgical experience.
However, it is important to note that scopoline has the potential to cause hallucinations, amnesia, and delirium when used inappropriately at higher doses. Due to these risks and its potential for abuse, scopoline is classified as a controlled substance in many countries. This highlights the need for careful regulation and responsible use of scopoline in medical settings.
Check Digit Verification of cas no
The CAS Registry Mumber 487-27-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 7 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 487-27:
(5*4)+(4*8)+(3*7)+(2*2)+(1*7)=84
84 % 10 = 4
So 487-27-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H13NO2/c1-9-5-2-4-3-6(9)8(11-4)7(5)10/h4-8,10H,2-3H2,1H3/t4-,5-,6+,7+,8-/m0/s1
487-27-4Relevant academic research and scientific papers
Enzymatic Resolution of Tropinone Derivatives
Cramer, Nicolai,Laschat, Sabine,Baro, Angelika
, p. 2178 - 2181 (2007/10/03)
The lipase-mediated kinetic resolution of racemic scopoline [(±)-4] and 6-hydroxytropinone [(±)-7] is reported. Whereas (±)-4 is difficult to resolve due to steric hindrance of the hydroxy function, the resolution of (±)-7 with vinyl acetate as acyl donor gave alcohol (+)-7 and the corresponding acetate (-)-9 with high enantiomeric excess. In case of the optimal result of 99% ee for (+)-7 and 80% ee for (-)-9, an E-value of 35 was calculated. The preparative lipase-catalyzed resolution of (±)-7 resulted in almost enantiopure alcohol (+)-7 with >99% ee after one recrystallization.
An Efficient Route to the Tropane Alkaloids
Mann, John,Barbosa, Luiz-Claudio de Almeida
, p. 787 - 790 (2007/10/02)
We describe the use of diethylzinc in conjunction with polybromo ketones for the production of oxyallyls, and the interception of these intermediates by furans and methyl pyrrole-N-carboxylate.This methodology allows the production of gramme quantities of tropane alkaloids, and 2-substituted 8-oxabicyclooct-6-en-3-ones that have been either difficult or impossible to prepare.
