487-27-4 Usage
General Description
Scopoline, also known as scopolamine, is a naturally occurring chemical compound found in certain plants such as henbane, jimsonweed, and belladonna. It is a tropane alkaloid with potent anticholinergic effects, meaning it blocks the action of the neurotransmitter acetylcholine in the central and peripheral nervous systems. Scopoline is often used in medicine to treat motion sickness, nausea, and vomiting, as well as to induce sedation and relaxation in patients undergoing surgery or medical procedures. However, it is also known for its potential to cause hallucinations, amnesia, and delirium when used inappropriately at higher doses, making it a common ingredient in certain date-rape drugs. Due to its powerful effects and potential for abuse, scopoline is classified as a controlled substance in many countries.
Check Digit Verification of cas no
The CAS Registry Mumber 487-27-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 7 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 487-27:
(5*4)+(4*8)+(3*7)+(2*2)+(1*7)=84
84 % 10 = 4
So 487-27-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H13NO2/c1-9-5-2-4-3-6(9)8(11-4)7(5)10/h4-8,10H,2-3H2,1H3/t4-,5-,6+,7+,8-/m0/s1
487-27-4Relevant articles and documents
Enzymatic Resolution of Tropinone Derivatives
Cramer, Nicolai,Laschat, Sabine,Baro, Angelika
, p. 2178 - 2181 (2007/10/03)
The lipase-mediated kinetic resolution of racemic scopoline [(±)-4] and 6-hydroxytropinone [(±)-7] is reported. Whereas (±)-4 is difficult to resolve due to steric hindrance of the hydroxy function, the resolution of (±)-7 with vinyl acetate as acyl donor gave alcohol (+)-7 and the corresponding acetate (-)-9 with high enantiomeric excess. In case of the optimal result of 99% ee for (+)-7 and 80% ee for (-)-9, an E-value of 35 was calculated. The preparative lipase-catalyzed resolution of (±)-7 resulted in almost enantiopure alcohol (+)-7 with >99% ee after one recrystallization.
