68307-67-5

Basic information

• Product Name: (2-CHLORO-BENZYL)-TRIMETHYL-SILANE
• Synonyms: (2-CHLORO-BENZYL)-TRIMETHYL-SILANE;(2-chlorophenyl)methyl-trimethylsilane
• CAS NO: 68307-67-5
• Molecular Formula: C₁₀H₁₅ClSi
• Molecular Weight: 198.7646
• Product Categories: pharmacetical
• Mol File: 68307-67-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 222-223 °C
• Appearance: /
• Density: 0.979±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (2-CHLORO-BENZYL)-TRIMETHYL-SILANE(CAS DataBase Reference)
• NIST Chemistry Reference: (2-CHLORO-BENZYL)-TRIMETHYL-SILANE(68307-67-5)
• EPA Substance Registry System: (2-CHLORO-BENZYL)-TRIMETHYL-SILANE(68307-67-5)

Safety Data

• Hazardous Substances Data: 68307-67-5(Hazardous Substances Data)

Usage

General Description

(2-Chloro-benzyl)-trimethyl-silane is a chemical compound that belongs to the class of organosilicon compounds. It is a colorless liquid with a molecular formula of C10H15ClSi. (2-CHLORO-BENZYL)-TRIMETHYL-SILANE is widely used as a reagent in organic synthesis, specifically in the production of various silicon-based materials. Its high reactivity and ability to undergo various chemical reactions make it valuable in the production of polymers, pharmaceuticals, and agrochemicals. Additionally, it is also utilized as a coupling agent in the manufacturing of surface coatings, adhesives, and sealants. Due to its importance in the field of organic chemistry and industrial applications, (2-Chloro-benzyl)-trimethyl-silane is considered a versatile and valuable chemical compound.

Upstream product

• 694-80-4 2-bromo-1-chlorobenzene 
• 1822-00-0 trimethylsilylmethyllithium 
• 75-77-4 chloro-trimethyl-silane 
• 4206-67-1 iodo(trimethylsilyl)methane 
• 615-41-8 2-iodochlorobenzene 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 

Downstream Products

• 60-12-8 2-phenylethanol 
• 770-09-2 benzyltrimethylsilane 
• 108-88-3 toluene 
• 698-87-3 3-phenyl-2-propanol 
• 3883-13-4 2,2,2-trichloroethylbenzene 
• 100-51-6 benzyl alcohol 
• 49681-79-0 phenyl ethanol-d1 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 6669-13-2 t-butyl phenyl ether 
• 103-05-9 4-phenyl-2-methyl-2-butanol 
• 100-86-7 2-Methyl-1-phenyl-2-propanol 
• 81824-03-5 2-benzyl-1,4-dioxane 
• 1657-52-9 (E)-2-chlorostilbene 
• 53774-32-6 2-(2-chlorophenyl)-1-phenylethan-1-ol 

Relevant articles and documents

Murahashi Cross-Coupling at ?78 °C: A One-Pot Procedure for Sequential C?C/C?C, C?C/C?N, and C?C/C?S Cross-Coupling of Bromo-Chloro-Arenes

The coupling of organolithium reagents, including strongly hindered examples, at cryogenic temperatures (as low as ?78 °C) has been achieved with high-reactivity Pd-NHC catalysts. A temperature-dependent chemoselectivity trigger has been developed for the selective coupling of aryl bromides in the presence of chlorides. Building on this, a one-pot, sequential coupling strategy is presented for the rapid construction of advanced building blocks. Importantly, one-shot addition of alkyllithium compounds to Pd cross-coupling reactions has been achieved, eliminating the need for slow addition by syringe pump.

Synthesis of functionalized benzylsilanes from arylzinc compounds and (iodomethyl)trimethylsilane by means of a novel Rh catalysis

The catalytic activity of a Rh complex in cross-coupling between ArZnI and TMSCH2l was examined in which the Rh complex, generated in situ from [RhCl(1,5-cyclooctadiene)]2 and 1,1′-bis(diphenylphosphino)- ferrocene, exhibited excellent catalytic activity for the production of various functionalized benzylsilanes in good yields. From 31P NMR studies of various solutions containing several of the reaction components, confirmation of the rapid and quantitative transfer of aryl groups from ArZnI to the Rh complex to form arylrhodium species was ascertained. A catalytic cycle, commencing with the transmetalation, was thus proposed for the reaction.