68307-67-5

Usage

Uses

Used in Organic Synthesis:
(2-Chloro-benzyl)-trimethyl-silane is used as a reagent in organic synthesis for the production of various silicon-based materials. Its versatility in chemical reactions contributes to the creation of a wide range of products.
Used in Polymer Production:
In the polymer industry, (2-Chloro-benzyl)-trimethyl-silane is used as a component in the synthesis of polymers that have applications in various fields due to their unique properties.
Used in Pharmaceutical Industry:
(2-Chloro-benzyl)-trimethyl-silane is utilized in the production of pharmaceuticals, where its reactivity aids in the synthesis of drug compounds.
Used in Agrochemical Production:
This organosilicon compound is also used in the agrochemical sector, playing a role in the synthesis of chemicals that are vital for agricultural applications.
Used as a Coupling Agent in Manufacturing:
(2-Chloro-benzyl)-trimethyl-silane serves as a coupling agent in the production of surface coatings, adhesives, and sealants, enhancing the performance and properties of these materials.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 4206-67-1 iodo(trimethylsilyl)methane 
• 615-41-8 2-iodochlorobenzene 
• 694-80-4 2-bromo-1-chlorobenzene 
• 1822-00-0 trimethylsilylmethyllithium 

Downstream Products

• 53774-32-6 2-(2-chlorophenyl)-1-phenylethan-1-ol 
• 1657-52-9 (E)-2-chlorostilbene 
• 60-12-8 2-phenylethanol 
• 770-09-2 benzyltrimethylsilane 
• 108-88-3 toluene 
• 698-87-3 3-phenyl-2-propanol 
• 81824-03-5 2-benzyl-1,4-dioxane 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 100-86-7 2-Methyl-1-phenyl-2-propanol 
• 6669-13-2 t-butyl phenyl ether 
• 103-05-9 4-phenyl-2-methyl-2-butanol 
• 49681-79-0 phenyl ethanol-d1 
• 100-51-6 benzyl alcohol 
• 3883-13-4 2,2,2-trichloroethylbenzene 

Relevant academic research and scientific papers

Murahashi Cross-Coupling at ?78 °C: A One-Pot Procedure for Sequential C?C/C?C, C?C/C?N, and C?C/C?S Cross-Coupling of Bromo-Chloro-Arenes

The coupling of organolithium reagents, including strongly hindered examples, at cryogenic temperatures (as low as ?78 °C) has been achieved with high-reactivity Pd-NHC catalysts. A temperature-dependent chemoselectivity trigger has been developed for the selective coupling of aryl bromides in the presence of chlorides. Building on this, a one-pot, sequential coupling strategy is presented for the rapid construction of advanced building blocks. Importantly, one-shot addition of alkyllithium compounds to Pd cross-coupling reactions has been achieved, eliminating the need for slow addition by syringe pump.

α,n-didehydrotoluenes by photoactivation of (chlorobenzyl) trimethylsilanes: An alternative to enyne-allenes cyclization

Doubly radical: A novel entry to ?,n-didehydrotoluene (DHT) diradicals is disclosed and proceeds through the photochemical activation of (chlorobenzyl)trimethylsilanes with chloride loss and elimination of the SiMe3+ group (see scheme). The products formed in solution are indicative of the intermediacy of the three isomers of the ?,n-DHT

Synthesis of functionalized benzylsilanes from arylzinc compounds and (iodomethyl)trimethylsilane by means of a novel Rh catalysis

The catalytic activity of a Rh complex in cross-coupling between ArZnI and TMSCH2l was examined in which the Rh complex, generated in situ from [RhCl(1,5-cyclooctadiene)]2 and 1,1′-bis(diphenylphosphino)- ferrocene, exhibited excellent catalytic activity for the production of various functionalized benzylsilanes in good yields. From 31P NMR studies of various solutions containing several of the reaction components, confirmation of the rapid and quantitative transfer of aryl groups from ArZnI to the Rh complex to form arylrhodium species was ascertained. A catalytic cycle, commencing with the transmetalation, was thus proposed for the reaction.

AN ELECTROREDUCTIVE SYNTHESIS OF ALLYLSILANES AND BENZYLSILANES

The electrochemical reduction of benzyl and allyl halides carried out in the presence of chlorotrimethylsilane afforded the corresponding benzylsilanes and allylsilanes in satisfactory yields.