6833-52-9

Upstream product

• 533-58-4 2-Iodophenol 
• 598-72-1 2-Bromopropionic acid 

Downstream Products

• 1134193-52-4 3,4-dihydro-2-methyl-4-(4-methylphenyl)-3-oxo-2H-1,4-benzoxazine 
• 1134193-53-5 2-methyl-4-m-tolyl-2H-1,4-benzoxazin-3(4H)-one 
• 1134193-55-7 4-(4-methoxyphenyl)-2-methyl-2H-benzo[b]-[1,4]oxazin-3(4H)-one 
• 1195764-58-9 2-methyl-4-phenyl-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 626225-52-3 4-benzyl-2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1374302-78-9 4-butyl-2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 1304876-41-2 C₁₃H₁₈INO₂ 
• 1374302-80-3 C₁₇H₁₇NO₂ 
• 1374302-81-4 C₁₅H₁₂ClNO₂ 
• 1374302-85-8 2-(o-iodophenoxy)acyl chloride 
• 10057-04-2 (R)-2-(2-iodophenoxy)propanoic acid 
• 10442-43-0 (S)-2-(2-iodophenoxy)propionic acid 

Relevant academic research and scientific papers

Access to Optically Enriched α-Aryloxycarboxylic Esters via Carbene-Catalyzed Dynamic Kinetic Resolution and Transesterification

Optically active α-aryloxycarboxylic acids and their derivatives are important functional molecules. Disclosed here is a carbene-catalyzed dynamic kinetic resolution and transesterification reaction for access to this class of molecules with up to 99% yields and 99:1 er values. Addition of a chiral carbene catalyst to the ester substrate leads to two diastereomeric azolium ester intermediates that can quickly epimerize to each other and thus allows for effective dynamic kinetic resolution to be realized. The optically enriched ester products from our reaction can be quickly transformed to chiral herbicides and other bioactive molecules.

Copper-catalyzed one-pot synthesis of 2H-1,4-benzoxazin-3-(4H)-ones from 2-(o-haloaryloxy)acyl chlorides and primary amines

A facile and efficient Cu(I)-catalyzed one-pot synthesis of 2H-1,4-benzoxazin-3-(4H)-one derivatives has been developed. The condensation between 2-(o-haloaryloxy)acyl chlorides and primary amines followed by Cu(I)-catalyzed intramolecular C-N bond coupling afforded a variety of 2H-1,4-benzoxazin-3-(4H)-ones in good to excellent yields. Diversified substitutents on the 4-position could be conveniently introduced. ARKAT-USA, Inc.