Synthesis p. 3947 - 3955 (2015)
Update date:2022-08-04
Topics:
Dos Santos, Josiane M.
Da Silveira, Alessandra S.
Souza, Laura A.
Lobo, Marcio M.
Bonacorso, Helio G.
Martins, Marcos A. P.
Zanatta, Nilo
This study reports a simple and highly regioselective synthesis of a new series of 3,6-disubstituted 2-(methylsulfanyl)pyrimidin-4(3H)-ones, in which the 6-substituents are methyl or aryl groups and the 3-substituents are alkyl, allyl, phenyl, benzyl, or 2-phenylethyl groups. The products are obtained in good yields by cyclocondensation of the appropriate 4-substituted 4-methoxy-1,1,1-trichloroalk-3-en-2-ones with nonsymmetric 1-substituted 2-methylisothiourea sulfates under mild basic conditions.
View MoreTaizhou YOJOY Chemical Co., Ltd.
Contact:13857143241
Address:Yangfu Industrial Park, Xianju, Zhejiang, P. R. China
Zhejiang PRIMAR Import & Export Trade Co., Ltd.
Contact:86-570-3630818
Address:No.1Puzhuyuan,Quhua,Zhejiang Province,China324004
website:http://www.enbridgepharm.com
Contact:+86-510-83591909
Address:Huishan Zone, Wuxi City, Jiangsu Province, P.R.China
Hunan Dinuo Pharmaceutical Co.,Ltd.
Contact:86-731-88280100*8561
Address:Bio-pharmaceutical industrial park, Liuyang, Hunan, China
Shanghai Sungo Technology Chemical Co., Ltd
Contact:0086-21-51385579
Address:Room2010, F/20, Tonghua Plaza, NO 345 Jinxiang Road, Jinqiao Export Processing Zone, Shanghai, 201206 P.R.CHINA
Doi:10.1021/ja01629a104
(1955)Doi:10.1016/j.tet.2004.01.032
(2004)Doi:10.1016/S0040-4039(00)99502-9
(1989)Doi:10.1016/0022-2860(79)80097-6
(1979)Doi:10.1021/jo01320a008
(1979)Doi:10.1007/BF00779215
()